slc25a25a solute carrier family 25 member 25a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc25a25aprovided by ZNC
Official Full Name: solute carrier family 25 member 25aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2396
See related: Ensembl:ENSDARG00000010572 AllianceGenome:ZFIN:ZDB-GENE-040426-2396
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: slc25a; slc25a25; zgc:77454; wu:fb13d12; wu:fd14e03
Summary: Predicted to enable ATP transmembrane transporter activity. Predicted to act upstream of or within transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Is expressed in brain; head; inner ear; and somite. Orthologous to human SLC25A25 (solute carrier family 25 member 25). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (2606067..2616128, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (2547524..2557585, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 in mitochondrial function via its association with several mitochondrial proteins.
Title: Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fd14e03.x1 (e-PCR)
- UniSTS:195199

AI667650 (e-PCR)
- UniSTS:206064

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: calcium-binding mitochondrial carrier protein SCaMC-2-A

Names: small calcium-binding mitochondrial carrier protein 2-A; solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25; solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a; solute carrier family 25 member 25; solute carrier family 25 member 25-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213257.1 → NP_998422.1 calcium-binding mitochondrial carrier protein SCaMC-2-A

See identical proteins and their annotated locations for NP_998422.1

Status: PROVISIONAL

Source sequence(s)

BC066404

UniProtKB/Swiss-Prot

Q6NYZ6

Related

ENSDARP00000008863.6, ENSDART00000027214.7

Conserved Domains (3) summary

pfam00153
Location:276 → 369

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:83 → 138

EF-hand_7; EF-hand domain pair

cl08302
Location:82 → 141

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...