abraxas2 abraxas 2, BRISC complex subunit [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abraxas2provided by ZNC
Official Full Name: abraxas 2, BRISC complex subunitprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2491
See related: Ensembl:ENSDARG00000098907 AllianceGenome:ZFIN:ZDB-GENE-040426-2491
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fam175b; abraxas2b; zgc:85800; wu:fi33f11
Summary: Predicted to enable microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore and mitotic spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm; microtubule; and spindle pole. Predicted to be active in nucleus. Orthologous to human ABRAXAS2 (abraxas 2, BRISC complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (31805576..31819832, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (31788601..31802863, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BRISC complex subunit Abraxas 2

Names: BRISC complex subunit abraxas 2; abraxas 2b, BRISC complex subunit; family with sequence similarity 175, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213295.1 → NP_998460.1 BRISC complex subunit Abraxas 2

See identical proteins and their annotated locations for NP_998460.1

Status: PROVISIONAL

Source sequence(s)

BC067636

UniProtKB/TrEMBL

Q6NWD2

Conserved Domains (1) summary

pfam07194
Location:92 → 165

P2; P2 response regulator binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

31805576..31819832 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068214379.1 → XP_068070480.1 BRISC complex subunit Abraxas 2 isoform X1
XM_009293129.4 → XP_009291404.1 BRISC complex subunit Abraxas 2 isoform X1

UniProtKB/Swiss-Prot

A0A8M3AJY3, A0A8M3AUE4, Q6NWD2

Related

ENSDARP00000136248.1, ENSDART00000160281.2

Conserved Domains (2) summary

pfam07194
Location:197 → 270

P2; P2 response regulator binding domain

pfam11825
Location:278 → 352

Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1