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mre11a MRE11 homolog A, double strand break repair nuclease [ Danio rerio (zebrafish) ]

Gene ID: 406637, updated on 2-Nov-2024

Summary

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Official Symbol
mre11aprovided by ZNC
Official Full Name
MRE11 homolog A, double strand break repair nucleaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2638
See related
Ensembl:ENSDARG00000105014 AllianceGenome:ZFIN:ZDB-GENE-040426-2638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc38f05; zgc:64018; wu:fc38f05; wu:faa63d12
Summary
Predicted to enable single-stranded DNA endodeoxyribonuclease activity. Acts upstream of or within hematopoietic stem cell homeostasis and regulation of telomere maintenance. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of Mre11 complex. Predicted to be active in site of double-strand break. Is expressed in alar plate midbrain region; digestive system; eye; immature eye; and midbrain. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mre11a in Genome Data Viewer
Location:
chromosome: 15
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (2857558..2887498)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (2894278..2924215)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene angiomotin like 1 Neighboring gene ankyrin repeat domain 49 Neighboring gene guanylate cyclase activator 1C Neighboring gene chromosome 15 C3orf52 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival. Lee L, et al. Sci Adv, 2021 Sep 24. PMID 34559557, Free PMC Article
  2. Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Zaksauskaite R, et al. Sci Adv, 2021 Jan. PMID 33514542, Free PMC Article
  3. Knock-In Strategy for Editing Human and Zebrafish Mitochondrial DNA Using Mito-CRISPR/Cas9 System. Bian WP, et al. ACS Synth Biol, 2019 Apr 19. PMID 30955321
  4. Cellular responses to ionizing radiation change quickly over time during early development in zebrafish. Honjo Y, et al. Cell Biol Int, 2019 May. PMID 30791195, Free PMC Article
  5. In vitro and in vivo studies of oxidative stress responses against acrylamide toxicity in zebrafish. Komoike Y, et al. J Hazard Mater, 2019 Mar 5. PMID 30453236

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3'-5'-DNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic DNA double-strand break formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Mre11 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Mre11 complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
double-strand break repair protein MRE11
Names
MRE11 homolog, double strand break repair nuclease A
meiotic recombination 11 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320259.1 → NP_001307188.1  double-strand break repair protein MRE11

    Status: VALIDATED

    Source sequence(s)
    CABZ01086035, CABZ01086036, CABZ01086037, CABZ01086038
    UniProtKB/TrEMBL
    A0A0R4ITV5, A0A8M9QPT3
    Related
    ENSDARP00000139437.1, ENSDART00000163434.3
    Conserved Domains (1) summary
    cl27188
    Location:11 → 403
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    2857558..2887498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481375.2 → XP_021337050.1  double-strand break repair protein MRE11 isoform X1

    UniProtKB/TrEMBL
    A0A0R4ITV5, A0A8M9QPT3
    Conserved Domains (1) summary
    cl27188
    Location:11 → 403
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001407.1: Suppressed sequence

    Description
    NM_001001407.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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