U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

tfdp1a transcription factor Dp-1, a [ Danio rerio (zebrafish) ]

Gene ID: 406813, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
tfdp1aprovided by ZNC
Official Full Name
transcription factor Dp-1, aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2883
See related
Ensembl:ENSDARG00000019293 AllianceGenome:ZFIN:ZDB-GENE-040426-2883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tfdp1l; zgc:55487; wu:fb94b07; wu:fc52a06
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to contribute to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription and regulation of cell cycle. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in mismatch repair cancer syndrome. Orthologous to human TFDP1 (transcription factor Dp-1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See tfdp1a in Genome Data Viewer
Location:
chromosome: 9
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (34950941..34968648)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (35141756..35159463)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 16 homolog (S. cerevisiae) Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 2a Neighboring gene methyltransferase 21C, AARS1 lysine b Neighboring gene si:ch211-160b11.4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and functional characterization of the transcription factor coding Dp1 gene in large yellow croaker Pseudosciaena crocea. Cai X, et al. Heliyon, 2021 Feb. PMID 33718639, Free PMC Article
  2. Distinct requirements of E2f4 versus E2f5 activity for multiciliated cell development in the zebrafish embryo. Chong YL, et al. Dev Biol, 2018 Nov 15. PMID 30218642
  3. Conservation as well as divergence in Mcidas function underlies the differentiation of multiciliated cells in vertebrates. Zhou F, et al. Dev Biol, 2020 Sep 15. PMID 32735790
  4. Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history. Castro LF, et al. Proc Biol Sci, 2014 Jan 22. PMID 24307675, Free PMC Article
  5. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription factor Dp-1a
Names
transcription factor Dp-1, like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213492.2 → NP_998657.1  transcription factor Dp-1a

    See identical proteins and their annotated locations for NP_998657.1

    Status: VALIDATED

    Source sequence(s)
    CR936415
    UniProtKB/TrEMBL
    B2GT80, Q803N1
    Related
    ENSDARP00000072266.4, ENSDART00000077800.6
    Conserved Domains (3) summary
    cd14458
    Location:198 → 244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:115 → 193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200 → 339
    DP; Transcription factor DP

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    34950941..34968648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167824.5 → XP_005167881.1  transcription factor Dp-1a isoform X1

    See identical proteins and their annotated locations for XP_005167881.1

    UniProtKB/TrEMBL
    B2GT80, Q803N1
    Conserved Domains (3) summary
    cd14458
    Location:198 → 244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:115 → 193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200 → 339
    DP; Transcription factor DP

  2. XM_009304816.3 → XP_009303091.1  transcription factor Dp-1a isoform X1

    See identical proteins and their annotated locations for XP_009303091.1

    UniProtKB/TrEMBL
    B2GT80, Q803N1
    Conserved Domains (3) summary
    cd14458
    Location:198 → 244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:115 → 193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200 → 339
    DP; Transcription factor DP

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394760.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    241548..259296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools