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ptpn4b protein tyrosine phosphatase non-receptor type 4b [ Danio rerio (zebrafish) ]

Gene ID: 407634, updated on 11-Apr-2024

Summary

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Official Symbol
ptpn4bprovided by ZNC
Official Full Name
protein tyrosine phosphatase non-receptor type 4bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6259
See related
Ensembl:ENSDARG00000000183 AllianceGenome:ZFIN:ZDB-GENE-030131-6259
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ptpn4a; fi40g11; wu:fi40g11; si:rp71-1n18.2
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Orthologous to human PTPN4 (protein tyrosine phosphatase non-receptor type 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See ptpn4b in Genome Data Viewer
Location:
chromosome: 22
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (11779834..11847366, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (11750157..11817701, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene keratin 97 Neighboring gene keratin 96 Neighboring gene muscle RAS oncogene homolog b Neighboring gene parathyroid hormone 2 receptor b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Wu W, et al. Sci Rep, 2017 Aug 16. PMID 28814789, Free PMC Article
  2. Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. van Eekelen M, et al. PLoS One, 2010 Sep 3. PMID 20838449, Free PMC Article
  3. Zebrafish as a model to study PTPs during development. Paardekooper Overman J, et al. Methods, 2014 Jan 15. PMID 23974070
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein tyrosine phosphatase, non-receptor type 4b; tyrosine-protein phosphatase non-receptor type 4b
Names
protein tyrosine phosphatase MEG1
protein tyrosine phosphatase MEG1b
protein tyrosine phosphatase, non-receptor type 4, b
protein tyrosine phosphatase, non-receptor type 4a
NP_001037778.2
XP_005174003.1
XP_009294371.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044313.2 → NP_001037778.2  tyrosine-protein phosphatase non-receptor type 4b

    Status: PROVISIONAL

    Source sequence(s)
    AL645755
    UniProtKB/TrEMBL
    A0A8M1N938, Q1MTL1
    Related
    ENSDARP00000105661.2, ENSDART00000125423.4
    Conserved Domains (8) summary
    smart00194
    Location:662 → 910
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:687 → 909
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:519 → 606
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:122 → 214
    FERM_B-lobe; FERM domain B-lobe
    pfam08736
    Location:325 → 365
    FA; FERM adjacent (FA)
    pfam09379
    Location:33 → 97
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    11779834..11847366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009296096.3 → XP_009294371.1  protein tyrosine phosphatase, non-receptor type 4b isoform X2

    UniProtKB/TrEMBL
    A0A8M3B5D0
    Conserved Domains (8) summary
    smart00194
    Location:661 → 914
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:686 → 913
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:518 → 605
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:122 → 214
    FERM_B-lobe; FERM domain B-lobe
    pfam08736
    Location:325 → 365
    FA; FERM adjacent (FA)
    pfam09379
    Location:33 → 97
    FERM_N; FERM N-terminal domain

  2. XM_005173946.4 → XP_005174003.1  protein tyrosine phosphatase, non-receptor type 4b isoform X1

    UniProtKB/TrEMBL
    A0A8M2BLA0, F1QFY3
    Related
    ENSDARP00000000192.10, ENSDART00000000192.10
    Conserved Domains (8) summary
    smart00194
    Location:662 → 915
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:687 → 914
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:519 → 606
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:122 → 214
    FERM_B-lobe; FERM domain B-lobe
    pfam08736
    Location:325 → 365
    FA; FERM adjacent (FA)
    pfam09379
    Location:33 → 97
    FERM_N; FERM N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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