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ptpn3 protein tyrosine phosphatase non-receptor type 3 [ Danio rerio (zebrafish) ]

Gene ID: 407635, updated on 2-Nov-2024

Summary

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Official Symbol
ptpn3provided by ZNC
Official Full Name
protein tyrosine phosphatase non-receptor type 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2934
See related
Ensembl:ENSDARG00000055784 AllianceGenome:ZFIN:ZDB-GENE-030131-2934
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc21h03; wu:fc21h03
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in developmental process. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Is expressed in liver. Orthologous to human PTPN3 (protein tyrosine phosphatase non-receptor type 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ptpn3 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (26547221..26600625)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (26673543..26727181)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene L3MBTL histone methyl-lysine binding protein 1b Neighboring gene serum/glucocorticoid regulated kinase 2b Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene uncharacterized LOC137487907 Neighboring gene epithelial splicing regulatory protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. SOCS1 and SOCS3 are the main negative modulators of the somatotrophic axis in liver of homozygous GH-transgenic zebrafish (Danio rerio). Studzinski AL, et al. Gen Comp Endocrinol, 2009 Mar. PMID 18955058
  2. Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Wu W, et al. Sci Rep, 2017 Aug 16. PMID 28814789, Free PMC Article
  3. Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. van Eekelen M, et al. PLoS One, 2010 Sep 3. PMID 20838449, Free PMC Article
  4. Zebrafish as a model to study PTPs during development. Paardekooper Overman J, et al. Methods, 2014 Jan 15. PMID 23974070
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in developmental process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 3
Names
PTP-H1
protein tyrosine phosphatase H1
XP_687930.5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    26547221..26600625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_682838.10 → XP_687930.5  tyrosine-protein phosphatase non-receptor type 3

    UniProtKB/TrEMBL
    A0A8N7UQV2, F1QLN8
    Related
    ENSDARP00000118507.1, ENSDART00000141393.2
    Conserved Domains (7) summary
    smart00194
    Location:579 → 829
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:33 → 223
    B41; Band 4.1 homologues
    cd00047
    Location:602 → 828
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:439 → 526
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00373
    Location:117 → 223
    FERM_M; FERM central domain
    pfam09379
    Location:35 → 98
    FERM_N; FERM N-terminal domain
    cl17171
    Location:217 → 309
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version

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