tcn2 transcobalamin II [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tcn2provided by ZNC
Official Full Name: transcobalamin IIprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4648
See related: Ensembl:ENSDARG00000036481 AllianceGenome:ZFIN:ZDB-GENE-030131-4648
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tcn2l; wu:fd46e10; si:ch211-102c2.6
Summary: Enables cobalamin binding activity. Acts upstream of or within cobalamin transport. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in intestine; liver; and yolk syncytial layer. Used to study vitamin B12 deficiency. Human ortholog(s) of this gene implicated in Parkinson's disease; megaloblastic anemia; and transcobalamin II deficiency. Orthologous to human TCN2 (transcobalamin 2). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (26795502..26806101)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (26195349..26205948)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of the Vitamin B-12 Transport Protein Tcn2 Results in Maternally Inherited Growth and Developmental Defects in Zebrafish.
Title: Loss of the Vitamin B-12 Transport Protein Tcn2 Results in Maternally Inherited Growth and Developmental Defects in Zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

G39229 (e-PCR)
- UniSTS:2600

fd46e10.x1 (e-PCR)
- UniSTS:204341

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cobalamin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cobalamin binding	IDA Inferred from Direct Assay more info	PubMed
enables cobalamin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cobalamin transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cobalamin transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cobalamin transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cobalt ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcobalamin-2

Names: transcobalamin II, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001123231.2 → NP_001116703.1 transcobalamin-2 precursor

Status: VALIDATED

Source sequence(s)

CU041374, EH509290, EH535398

UniProtKB/TrEMBL

A0A8M1NIB7, F2Z4S3

Related

ENSDARP00000053000.4, ENSDART00000053001.6

Conserved Domains (2) summary

pfam01122
Location:17 → 318

Cobalamin_bind; Eukaryotic cobalamin-binding protein

pfam14478
Location:347 → 421

DUF4430; Domain of unknown function (DUF4430)