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hbegfb heparin-binding EGF-like growth factor b [ Danio rerio (zebrafish) ]

Gene ID: 407664, updated on 14-Nov-2024

Summary

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Official Symbol
hbegfbprovided by ZNC
Official Full Name
heparin-binding EGF-like growth factor bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070820-6
See related
Ensembl:ENSDARG00000031246 AllianceGenome:ZFIN:ZDB-GENE-070820-6
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hbegf; zgc:165443
Summary
Predicted to enable epidermal growth factor receptor binding activity and growth factor activity. Acts upstream of or within heart contraction. Predicted to be located in membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See hbegfb in Genome Data Viewer
Location:
chromosome: 21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (30161295..30168949, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (30124603..30132261, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 23 member 1 Neighboring gene prefoldin subunit 1 Neighboring gene heterogeneous nuclear ribonucleoprotein H1, like Neighboring gene uncharacterized LOC137488826

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. HB-EGF promotes progenitor cell proliferation and sensory neuron regeneration in the zebrafish olfactory epithelium. Sireci S, et al. FEBS J, 2024 May. PMID 38088047
  2. Differential regulation of betacellulin and heparin-binding EGF-like growth factor in cultured zebrafish ovarian follicle cells by EGF family ligands. Tse AC, et al. Comp Biochem Physiol A Mol Integr Physiol, 2009 May. PMID 19000772
  3. Lineage-specific co-evolution of the Egf receptor/ligand signaling system. Laisney JA, et al. BMC Evol Biol, 2010 Jan 27. PMID 20105326, Free PMC Article
  4. Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration. Schall KA, et al. Am J Physiol Gastrointest Liver Physiol, 2015 Aug 1. PMID 26089336, Free PMC Article
  5. Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer. Cigliola V, et al. Nat Commun, 2023 Aug 11. PMID 37567873, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HB-EGF promotes progenitor cell proliferation and sensory neuron regeneration in the zebrafish olfactory epithelium.
    Title: HB-EGF promotes progenitor cell proliferation and sensory neuron regeneration in the zebrafish olfactory epithelium.
  2. These results suggest that there is an EGF signaling network in the zebrafish ovarian follicle, and the functionality of this network is self-regulated by its own members.
    Title: Differential regulation of betacellulin and heparin-binding EGF-like growth factor in cultured zebrafish ovarian follicle cells by EGF family ligands.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heparin-binding EGF-like growth factor b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100401.2 → NP_001093871.2  heparin-binding EGF-like growth factor b precursor

    Status: VALIDATED

    Source sequence(s)
    BX510945, EH542909, EH548388, EH569504
    UniProtKB/TrEMBL
    A0A8M1NE67
    Related
    ENSDARP00000152981.1, ENSDART00000193171.1
    Conserved Domains (1) summary
    PHA02887
    Location:123 → 163
    PHA02887; EGF-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    30161295..30168949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161297.5 → XP_005161354.1  heparin-binding EGF-like growth factor b isoform X1

    UniProtKB/TrEMBL
    A0A8M2B880
    Related
    ENSDARP00000109242.2, ENSDART00000130820.4
    Conserved Domains (1) summary
    PHA02887
    Location:123 → 163
    PHA02887; EGF-like protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version

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