U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

tcf12 transcription factor 12 [ Danio rerio (zebrafish) ]

Gene ID: 407985, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
tcf12provided by ZNC
Official Full Name
transcription factor 12provided by ZNC
Primary source
ZFIN:ZDB-GENE-040516-11
See related
Ensembl:ENSDARG00000004714 AllianceGenome:ZFIN:ZDB-GENE-040516-11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TCF-12; zgc:85956; wu:fb74g05; wu:fc43e06; zgc:110341
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within neuron projection development. Predicted to be located in chromatin. Predicted to be part of transcription regulator complex. Is expressed in several structures, including cranial vault; mesoderm; nervous system; neural tube; and presumptive diencephalon. Human ortholog(s) of this gene implicated in craniosynostosis and hypogonadotropic hypogonadism. Orthologous to human TCF12 (transcription factor 12). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See tcf12 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (52516711..52709860, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (52241639..52434819, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene myocardial zonula adherens protein Neighboring gene cingulin-like 1 Neighboring gene zinc finger protein 280D Neighboring gene mitochondrial methionyl-tRNA formyltransferase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. On the traces of tcf12: Investigation of the gene expression pattern during development and cranial suture patterning in zebrafish (Danio rerio). Blümel R, et al. PLoS One, 2019. PMID 31188878, Free PMC Article
  2. Dithiocarbamates induce craniofacial abnormalities and downregulate sox9a during zebrafish development. van Boxtel AL, et al. Toxicol Sci, 2010 Sep. PMID 20530235
  3. TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci. Davis EE, et al. Hum Mol Genet, 2020 Aug 11. PMID 32620954, Free PMC Article
  4. Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome. Teng CS, et al. Elife, 2018 Oct 25. PMID 30375332, Free PMC Article
  5. Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Buono L, et al. Nat Commun, 2021 Jun 23. PMID 34162866, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci.
    Title: TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci.
  2. we show that combinatorial loss of TCF12 and TWIST1 homologs in zebrafish also results in specific loss of the coronal suture
    Title: Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription factor 12
Names
TF12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214816.1 → NP_999981.1  transcription factor 12

    See identical proteins and their annotated locations for NP_999981.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070024
    Related
    ENSDARP00000004196.8, ENSDART00000009938.11
    Conserved Domains (1) summary
    smart00353
    Location:434 → 487
    HLH; helix loop helix domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    52516711..52709860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166511.4 → XP_005166568.1  transcription factor 12 isoform X6

    UniProtKB/TrEMBL
    A0A1L1QZA0, A0A8M2BE12
    Related
    ENSDARP00000143021.1, ENSDART00000174117.2
    Conserved Domains (1) summary
    smart00353
    Location:590 → 643
    HLH; helix loop helix domain

  2. XM_005166508.4 → XP_005166565.1  transcription factor 12 isoform X3

    UniProtKB/TrEMBL
    A0A1L1QZH9, A0A8M2BDZ9
    Related
    ENSDARP00000143100.1, ENSDART00000174355.2
    Conserved Domains (1) summary
    smart00353
    Location:614 → 667
    HLH; helix loop helix domain

  3. XM_005166510.4 → XP_005166567.1  transcription factor 12 isoform X5

    UniProtKB/TrEMBL
    A0A8M2BDZ2
    Conserved Domains (1) summary
    smart00353
    Location:597 → 650
    HLH; helix loop helix domain

  4. XM_009303437.3 → XP_009301712.1  transcription factor 12 isoform X4

    UniProtKB/TrEMBL
    A0A8M3BB85
    Related
    ENSDARP00000123095.1, ENSDART00000131282.3
    Conserved Domains (1) summary
    smart00353
    Location:603 → 656
    HLH; helix loop helix domain

  5. XM_009303436.3 → XP_009301711.1  transcription factor 12 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AUI8
    Conserved Domains (1) summary
    smart00353
    Location:621 → 674
    HLH; helix loop helix domain

  6. XM_009303435.4 → XP_009301710.1  transcription factor 12 isoform X1

    UniProtKB/Swiss-Prot
    A0A0R4IBL7, A0A8M1PFS7, E9QDA6, Q6NSM7
    Related
    ENSDARP00000132258.1, ENSDART00000161387.3
    Conserved Domains (1) summary
    smart00353
    Location:627 → 680
    HLH; helix loop helix domain

  7. XM_009303439.3 → XP_009301714.1  transcription factor 12 isoform X7

    UniProtKB/TrEMBL
    A0A1L1QZR8, A0A8M3B4D1
    Related
    ENSDARP00000143194.1, ENSDART00000174292.2
    Conserved Domains (1) summary
    smart00353
    Location:452 → 505
    HLH; helix loop helix domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0R4IBL7.1 GenPept UniProtKB/Swiss-Prot:A0A0R4IBL7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.