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dnaaf11 dynein axonemal assembly factor 11 [ Danio rerio (zebrafish) ]

Gene ID: 432388, updated on 2-Nov-2024

Summary

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Official Symbol
dnaaf11provided by ZNC
Official Full Name
dynein axonemal assembly factor 11provided by ZNC
Primary source
ZFIN:ZDB-GENE-040827-2
See related
Ensembl:ENSDARG00000053318 AllianceGenome:ZFIN:ZDB-GENE-040827-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lrrc6; lrrc6l
Summary
Acts upstream of or within several processes, including cilium movement involved in cell motility; embryonic morphogenesis; and motile cilium assembly. Located in cytoplasm. Is expressed in several structures, including floor plate; forerunner cell group; olfactory pit; pronephros; and tail bud. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 19. Orthologous to human DNAAF11 (dynein axonemal assembly factor 11). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dnaaf11 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (43097086..43124031, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (43248680..43274606, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene HHLA1 neighbor of OC90 Neighboring gene potassium voltage-gated channel, KQT-like subfamily, member 3 Neighboring gene finTRIM family, member 13 Neighboring gene finTRIM family, member 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish. Ryan S, et al. Development, 2013 Nov. PMID 24130329, Free PMC Article
  2. Genetic defects of pronephric cilia in zebrafish. Zhao C, et al. Mech Dev, 2007 Aug. PMID 17576052
  3. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Sun Z, et al. Development, 2004 Aug. PMID 15269167
  4. Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility. Zhao L, et al. Proc Natl Acad Sci U S A, 2013 Jul 30. PMID 23858445, Free PMC Article
  5. Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Kishimoto N, et al. Dev Cell, 2008 Jun. PMID 18539122

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the Reptin-Lrrc6/Seahorse complex is involved in dynein arm formation.
    Title: Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility.
  2. the function of seahorse in cilia motility is separable from its function in other cilia-related phenotypes
    Title: Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning.
  3. Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways.
    Title: Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonemal dynein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cerebrospinal fluid circulation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cilium movement involved in cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within convergent extension involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic heart tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within establishment of localization in cell ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within heart jogging IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within motile cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within outer dynein arm assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within pronephros development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dynein axonemal particle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dynein axonemal assembly factor 11
Names
leucine rich repeat containing 6
leucine-rich repeat-containing 6 like
leucine-rich repeat-containing 6-like protein
leucine-rich repeat-containing protein 6
protein TILB homolog
sea
seahorse
unm tg238a
zar
zator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002311.1 → NP_001002311.1  dynein axonemal assembly factor 11

    See identical proteins and their annotated locations for NP_001002311.1

    Status: PROVISIONAL

    Source sequence(s)
    AY618925
    UniProtKB/Swiss-Prot
    B3DH20, Q6IVV9
    Related
    ENSDARP00000069830.3, ENSDART00000075347.5
    Conserved Domains (3) summary
    sd00031
    Location:23 → 45
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:46 → 86
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:46 → 98
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    43097086..43124031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171374.5 → XP_005171431.1  dynein axonemal assembly factor 11 isoform X1

    UniProtKB/Swiss-Prot
    B3DH20, Q6IVV9
    UniProtKB/TrEMBL
    A0A8M2BIP4, F1Q7C0
    Related
    ENSDARP00000113887.1, ENSDART00000132346.3
    Conserved Domains (3) summary
    sd00031
    Location:23 → 45
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:46 → 86
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:46 → 98
    LRR_8; Leucine rich repeat

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394511.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    262633..263123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B3DH20.1 GenPept UniProtKB/Swiss-Prot:B3DH20

Gene LinkOut

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