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agxta alanine--glyoxylate and serine--pyruvate aminotransferase a [ Danio rerio (zebrafish) ]

Gene ID: 436603, updated on 2-Nov-2024

Summary

Official Symbol
agxtaprovided by ZNC
Official Full Name
alanine--glyoxylate and serine--pyruvate aminotransferase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-16
See related
Ensembl:ENSDARG00000052099 AllianceGenome:ZFIN:ZDB-GENE-040718-16
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
agxtl; zgc:91879
Summary
Predicted to enable L-serine-pyruvate transaminase activity and alanine-glyoxylate transaminase activity. Predicted to be involved in glycine biosynthetic process, by transamination of glyoxylate. Predicted to be active in peroxisome. Is expressed in liver and pronephric duct. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate aminotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See agxta in Genome Data Viewer
Location:
chromosome: 6
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (27112884..27123307, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (27122323..27132746, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene BCL2 family apoptosis regulator BOK a Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene deoxythymidylate kinase (thymidylate kinase) Neighboring gene zgc:103559 Neighboring gene kinesin family member 1Aa

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-serine-pyruvate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-serine-pyruvate transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables alanine-glyoxylate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alanine-glyoxylate transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glycine biosynthetic process, by transamination of glyoxylate IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
alanine--glyoxylate and serine--pyruvate aminotransferase a
Names
alanine-glyoxylate aminotransferase a
alanine-glyoxylate aminotransferase, like
NP_001002331.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002331.1NP_001002331.1  alanine--glyoxylate and serine--pyruvate aminotransferase a

    See identical proteins and their annotated locations for NP_001002331.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076465
    UniProtKB/TrEMBL
    Q6DG86
    Related
    ENSDARP00000068371.4, ENSDART00000073881.5
    Conserved Domains (2) summary
    cd06451
    Location:22384
    AGAT_like; Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), ...
    COG0075
    Location:16386
    PucG; Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG [Amino acid transport and metabolism, Nucleotide transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    27112884..27123307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)