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akr7a3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) [ Danio rerio (zebrafish) ]

Gene ID: 436642, updated on 17-Aug-2024

Summary

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Official Symbol
akr7a3provided by ZNC
Official Full Name
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-62
See related
Ensembl:ENSDARG00000016649 AllianceGenome:ZFIN:ZDB-GENE-040718-62
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92502
Summary
Predicted to enable aldo-keto reductase (NADP) activity. Predicted to be active in cytoplasm. Is expressed in gut; liver; myotome; and optic vesicle. Orthologous to several human genes including AKR7A3 (aldo-keto reductase family 7 member A3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See akr7a3 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (41838801..41846060)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (41226571..41233830)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 2a Neighboring gene multiple EGF-like-domains 6b Neighboring gene MRT4 homolog, ribosome maturation factor Neighboring gene intermediate filament family orphan 2b Neighboring gene aldehyde dehydrogenase 4 family, member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative analysis of period genes in teleost fish genomes. Wang H. J Mol Evol, 2008 Jul. PMID 18535754
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aldo-keto reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aflatoxin B1 aldehyde reductase member 3
NP_001002369.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002369.1 → NP_001002369.1  aflatoxin B1 aldehyde reductase member 3

    See identical proteins and their annotated locations for NP_001002369.1

    Status: VALIDATED

    Source sequence(s)
    BC076040
    UniProtKB/TrEMBL
    A0A8M1N0E3, F6NHB2, Q6DHD5
    Related
    ENSDARP00000003850.6, ENSDART00000014871.7
    Conserved Domains (2) summary
    cd06660
    Location:2 → 310
    Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
    COG0667
    Location:2 → 319
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    41838801..41846060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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