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uqcrc2a ubiquinol-cytochrome c reductase core protein 2a [ Danio rerio (zebrafish) ]

Gene ID: 436930, updated on 12-Sep-2024

Summary

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Official Symbol
uqcrc2aprovided by ZNC
Official Full Name
ubiquinol-cytochrome c reductase core protein 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-405
See related
Ensembl:ENSDARG00000014794 AllianceGenome:ZFIN:ZDB-GENE-040718-405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb33d01; fc43c05; zgc:92453; wu:fb33d01; wu:fc43c05
Summary
Predicted to enable metal ion binding activity. Predicted to be active in mitochondrion. Is expressed in female organism. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See uqcrc2a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (58167269..58185030)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (58096729..58133545)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene si:ch211-256e16.3 Neighboring gene stonustoxin subunit beta-like Neighboring gene NACHT, LRR and PYD domains-containing protein 3 Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein a (U4/U6.U5) Neighboring gene protein NLRC3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mitochondrial dysfunction-based cardiotoxicity and neurotoxicity induced by pyraclostrobin in zebrafish larvae. Li H, et al. Environ Pollut, 2019 Aug. PMID 31078959
  2. Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Ayobahan SU, et al. Chemosphere, 2020 Feb. PMID 31726584
  3. Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Ferrante MI, et al. Hum Mol Genet, 2009 Jan 15. PMID 18971206, Free PMC Article
  4. Aclonifen causes developmental abnormalities in zebrafish embryos through mitochondrial dysfunction and oxidative stress. Lee JY, et al. Sci Total Environ, 2021 Jun 1. PMID 33548715
  5. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquinol-cytochrome c reductase core protein 2a
Names
ubiquinol-cytochrome c reductase core protein IIa
NP_001002657.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002657.2 → NP_001002657.2  ubiquinol-cytochrome c reductase core protein 2a

    Status: VALIDATED

    Source sequence(s)
    CT583687, EB969638, EH436572
    UniProtKB/TrEMBL
    A0A8M1N0Y0, F1QJE0
    Related
    ENSDARP00000015132.6, ENSDART00000010395.9
    Conserved Domains (3) summary
    COG0612
    Location:33 → 443
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    pfam00675
    Location:55 → 201
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:206 → 385
    Peptidase_M16_C; Peptidase M16 inactive domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    58167269..58185030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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