trim24 tripartite motif containing 24 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trim24provided by ZNC
Official Full Name: tripartite motif containing 24provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5913
See related: Ensembl:ENSDARG00000103350 AllianceGenome:ZFIN:ZDB-GENE-030131-5913
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tifa; tif1a; wu:fi24g04
Summary: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of transcription, DNA-templated. Predicted to be active in chromatin and nucleoplasm. Orthologous to human TRIM24 (tripartite motif containing 24). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (74141400..74205303)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (72666539..72730614)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc76b06.y1 (e-PCR)
- UniSTS:194470

fi24g04.x1 (e-PCR)
- UniSTS:197090

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription intermediary factor 1-alpha

Names: tif1 alpha; transcriptional intermediary factor 1 alpha; tripartite motif protein 24

NP_001002870.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002870.2 → NP_001002870.2 transcription intermediary factor 1-alpha

See identical proteins and their annotated locations for NP_001002870.2

Status: PROVISIONAL

Source sequence(s)

BC096849

UniProtKB/TrEMBL

Q4V9K7

Related

ENSDARP00000130383.1, ENSDART00000166994.2

Conserved Domains (7) summary

cd05502
Location:771 → 877

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00336
Location:132 → 176

BBOX; B-Box-type zinc finger

COG5034
Location:604 → 744

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd00021
Location:192 → 230

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

pfam14634
Location:51 → 103

zf-RING_5; zinc-RING finger domain

cl22851
Location:699 → 744

PHD_SF; PHD finger superfamily

cl23765
Location:237 → 363

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits