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fbxo44.5 F-box protein 44, tandem duplicate 5 [ Danio rerio (zebrafish) ]

Gene ID: 445148, updated on 2-Nov-2024

Summary

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Official Symbol
fbxo44.5provided by ZNC
Official Full Name
F-box protein 44, tandem duplicate 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-53
See related
Ensembl:ENSDARG00000012035 AllianceGenome:ZFIN:ZDB-GENE-040801-53
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:100832
Summary
Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO44 (F-box protein 44). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See fbxo44.5 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (16815372..16822859)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (16888853..16896516)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489159 Neighboring gene F-box protein 44, tandem duplicate 3 Neighboring gene uncharacterized LOC110438317 Neighboring gene F-box protein 6, tandem duplicate 2 Neighboring gene F-box protein 6, tandem duplicate 3 Neighboring gene ataxin-2 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC445148

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003542.2 → NP_001003542.2  uncharacterized protein LOC445148 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AL732515
    UniProtKB/TrEMBL
    A0A0R4I9Z2, A0A8M2B907, F1Q8M7, Q6DEK8
    Related
    ENSDARP00000118903.1, ENSDART00000143424.3
    Conserved Domains (2) summary
    pfam00646
    Location:1 → 46
    F-box; F-box domain
    pfam04300
    Location:67 → 241
    FBA; F-box associated region

  2. NM_001362483.1 → NP_001349412.1  uncharacterized protein LOC445148 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL732515
    UniProtKB/TrEMBL
    A0A0R4IQM2, A0A8M9P533, Q6DEK8
    Conserved Domains (2) summary
    pfam00646
    Location:30 → 75
    F-box; F-box domain
    pfam04300
    Location:96 → 270
    FBA; F-box associated region

  3. NM_001362484.1 → NP_001349413.1  uncharacterized protein LOC445148 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL732515
    UniProtKB/TrEMBL
    A0A0R4IQM2, A0A8M9P533, Q6DEK8
    Conserved Domains (2) summary
    pfam00646
    Location:30 → 75
    F-box; F-box domain
    pfam04300
    Location:96 → 270
    FBA; F-box associated region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    16815372..16822859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469787.2 → XP_021325462.1  uncharacterized protein LOC445148 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IQM2, A0A8M9P533, Q6DEK8
    Conserved Domains (2) summary
    pfam00646
    Location:30 → 75
    F-box; F-box domain
    pfam04300
    Location:96 → 270
    FBA; F-box associated region

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395360.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    270273..277758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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