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mzt2b mitotic spindle organizing protein 2B [ Danio rerio (zebrafish) ]

Gene ID: 445174, updated on 2-Nov-2024

Summary

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Official Symbol
mzt2bprovided by ZNC
Official Full Name
mitotic spindle organizing protein 2Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-87
See related
Ensembl:ENSDARG00000057928 AllianceGenome:ZFIN:ZDB-GENE-040801-87
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mzt2; fam128; zgc:101080
Summary
Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of gamma-tubulin ring complex. Predicted to be active in centrosome and spindle. Orthologous to several human genes including MZT2B (mitotic spindle organizing protein 2B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See mzt2b in Genome Data Viewer
Location:
chromosome: 21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (16079124..16087880, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (15983147..15991931, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 169 member Ab Neighboring gene LIM homeobox 5 Neighboring gene zgc:193801 Neighboring gene transfer RNA alanine (anticodon UGC)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Conserved Noncoding Sequences Regulate lhx5 Expression in the Zebrafish Forebrain. Sun L, et al. PLoS One, 2015. PMID 26147098, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-tubulin ring complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
mitotic-spindle organizing protein 2
Names
mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316932.1 → NP_001303861.1  mitotic-spindle organizing protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL953866, BI709411, CK396487, EH580697
    UniProtKB/TrEMBL
    A0A8M1P750, E9QFU9
    Related
    ENSDARP00000122770.1, ENSDART00000144955.2
    Conserved Domains (1) summary
    pfam12926
    Location:12 → 102
    MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

  2. NM_001316933.1 → NP_001303862.1  mitotic-spindle organizing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL953866, BI709411, CK396487, EH580697
    UniProtKB/TrEMBL
    A0A2R8PWK7, A0A8M1P2L9
    Related
    ENSDARP00000145303.1, ENSDART00000180621.1
    Conserved Domains (1) summary
    pfam12926
    Location:12 → 102
    MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

  3. NM_001316934.1 → NP_001303863.1  mitotic-spindle organizing protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AL953866, BI709411, CK396487
    UniProtKB/Swiss-Prot
    Q6DC17
    UniProtKB/TrEMBL
    A0A8M1P7U0, F1QI17
    Related
    ENSDARP00000114669.1, ENSDART00000135605.3
    Conserved Domains (1) summary
    pfam12926
    Location:12 → 102
    MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    16079124..16087880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DC17.1 GenPept UniProtKB/Swiss-Prot:Q6DC17

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.