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auh AU RNA binding protein/enoyl-CoA hydratase [ Danio rerio (zebrafish) ]

Gene ID: 445182, updated on 28-Oct-2024

Summary

Official Symbol
auhprovided by ZNC
Official Full Name
AU RNA binding protein/enoyl-CoA hydrataseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-95
See related
Ensembl:ENSDARG00000042975 AllianceGenome:ZFIN:ZDB-GENE-040801-95
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb81b10; zgc:101057
Summary
Predicted to enable enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 1 and renal tubular transport disease. Orthologous to human AUH (AU RNA binding methylglutaconyl-CoA hydratase). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See auh in Genome Data Viewer
Location:
chromosome: 10
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (5422545..5475977)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (5422241..5475673)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911708 Neighboring gene receptor tyrosine kinase-like orphan receptor 2 Neighboring gene nuclear factor, interleukin 3 regulated Neighboring gene spleen tyrosine kinase Neighboring gene DIRAS family GTPase 2 Neighboring gene PDZ and pleckstrin homology domains 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methylglutaconyl-CoA hydratase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
methylglutaconyl-CoA hydratase, mitochondrial
Names
AU RNA binding protein/enoyl-Coenzyme A hydratase
NP_001003576.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003576.2NP_001003576.2  methylglutaconyl-CoA hydratase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    CR848004, EH460121, EH506229
    UniProtKB/TrEMBL
    A0A8M1N1I7, F1RDX1
    Related
    ENSDARP00000063092.3, ENSDART00000063093.4
    Conserved Domains (1) summary
    cl23717
    Location:71325
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    5422545..5475977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)