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hibadha 3-hydroxyisobutyrate dehydrogenase a [ Danio rerio (zebrafish) ]

Gene ID: 445252, updated on 27-Mar-2024

Summary

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Official Symbol
hibadhaprovided by ZNC
Official Full Name
3-hydroxyisobutyrate dehydrogenase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-264
See related
Ensembl:ENSDARG00000102906 AllianceGenome:ZFIN:ZDB-GENE-040801-264
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb07f02; zgc:100804
Summary
Predicted to enable 3-hydroxyisobutyrate dehydrogenase activity. Predicted to be involved in valine catabolic process. Predicted to act upstream of or within branched-chain amino acid catabolic process. Predicted to be active in mitochondrion. Is expressed in mesenchyme pectoral fin and myoblast. Orthologous to human HIBADH (3-hydroxyisobutyrate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See hibadha in Genome Data Viewer
Location:
chromosome: 19
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (19600268..19657539)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (20027324..20084588)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 5a Neighboring gene JAZF zinc finger 1a Neighboring gene Tax1 (human T-cell leukemia virus type I) binding protein 1a Neighboring gene homeobox A13a Neighboring gene even-skipped homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Tri-phasic expression of posterior Hox genes during development of pectoral fins in zebrafish: implications for the evolution of vertebrate paired appendages. Ahn D, et al. Dev Biol, 2008 Oct 1. PMID 18638469
  2. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3-hydroxyisobutyrate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxyisobutyrate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within branched-chain amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in valine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in valine catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
3-hydroxyisobutyrate dehydrogenase a
NP_001003646.1
XP_009292434.1
XP_021323726.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003646.2 → NP_001003646.1  3-hydroxyisobutyrate dehydrogenase a

    See identical proteins and their annotated locations for NP_001003646.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078207
    UniProtKB/TrEMBL
    Q6DC72
    Related
    ENSDARP00000130898.1, ENSDART00000160134.2
    Conserved Domains (3) summary
    TIGR01692
    Location:37 → 324
    HIBADH; 3-hydroxyisobutyrate dehydrogenase
    pfam03446
    Location:32 → 193
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
    pfam14833
    Location:196 → 323
    NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    19600268..19657539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009294159.3 → XP_009292434.1  3-hydroxyisobutyrate dehydrogenase a isoform X2

    UniProtKB/TrEMBL
    A0A8M3AKW8
    Conserved Domains (2) summary
    pfam03446
    Location:32 → 193
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
    pfam14833
    Location:196 → 226
    NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

  2. XM_021468051.1 → XP_021323726.1  3-hydroxyisobutyrate dehydrogenase a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PN96
    Conserved Domains (1) summary
    cl25951
    Location:37 → 224
    NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
Nucleotide Protein Strain
Heading Accession and Version

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