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picalmb phosphatidylinositol binding clathrin assembly protein b [ Danio rerio (zebrafish) ]

Gene ID: 445286, updated on 2-Nov-2024

Summary

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Official Symbol
picalmbprovided by ZNC
Official Full Name
phosphatidylinositol binding clathrin assembly protein bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6795
See related
Ensembl:ENSDARG00000014137 AllianceGenome:ZFIN:ZDB-GENE-030131-6795
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
picalm; fa01d03; picalml; zgc:91993; wu:fa01d03; wu:fa05d03; wu:fb69g01; wu:fe17e02
Summary
Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle budding from presynaptic endocytic zone membrane. Predicted to act upstream of or within clathrin coat assembly. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and synaptic vesicle. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See picalmb in Genome Data Viewer
Location:
chromosome: 15
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (19727993..19772415, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (19792255..19836663, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:dkey-4p15.5 Neighboring gene synaptotagmin-like 2b Neighboring gene si:ch211-229d2.5 Neighboring gene zona pellucida-like domain containing 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in extrinsic component of presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol binding clathrin assembly protein b
Names
phosphatidylinositol binding clathrin assembly protein, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003741.1 → NP_001003741.1  phosphatidylinositol binding clathrin assembly protein b

    See identical proteins and their annotated locations for NP_001003741.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079523
    UniProtKB/TrEMBL
    A0A0R4IFT4, A0A8M1N1S6, F1R5M0, Q6AXI5
    Related
    ENSDARP00000131752.2, ENSDART00000159475.2
    Conserved Domains (2) summary
    pfam07651
    Location:19 → 282
    ANTH; ANTH domain
    pfam08287
    Location:265 → 344
    DASH_Spc19; Spc19

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    19727993..19772415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291642.4 → XP_009289917.1  phosphatidylinositol binding clathrin assembly protein b isoform X16

    UniProtKB/TrEMBL
    A0A8M3B110
    Conserved Domains (2) summary
    pfam07651
    Location:19 → 282
    ANTH; ANTH domain
    pfam08287
    Location:265 → 344
    DASH_Spc19; Spc19

  2. XM_068213529.1 → XP_068069630.1  phosphatidylinositol binding clathrin assembly protein b isoform X15

  3. XM_068213527.1 → XP_068069628.1  phosphatidylinositol binding clathrin assembly protein b isoform X12

    Related
    ENSDARP00000144339.2, ENSDART00000175502.2

  4. XM_068213526.1 → XP_068069627.1  phosphatidylinositol binding clathrin assembly protein b isoform X10

  5. XM_009291636.4 → XP_009289911.1  phosphatidylinositol binding clathrin assembly protein b isoform X4

    UniProtKB/TrEMBL
    A0A8M3AHB8
    Conserved Domains (1) summary
    pfam07651
    Location:19 → 282
    ANTH; ANTH domain

  6. XM_017359234.3 → XP_017214723.1  phosphatidylinositol binding clathrin assembly protein b isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z2V9

  7. XM_009291637.4 → XP_009289912.1  phosphatidylinositol binding clathrin assembly protein b isoform X7

    UniProtKB/TrEMBL
    A0A8M3B104
    Conserved Domains (1) summary
    pfam07651
    Location:19 → 286
    ANTH; ANTH domain

  8. XM_009291635.4 → XP_009289910.1  phosphatidylinositol binding clathrin assembly protein b isoform X2

    UniProtKB/TrEMBL
    A0A8M3APR9
    Conserved Domains (1) summary
    pfam07651
    Location:19 → 286
    ANTH; ANTH domain

  9. XM_009291641.4 → XP_009289916.1  phosphatidylinositol binding clathrin assembly protein b isoform X14

    UniProtKB/TrEMBL
    A0A8M3AHC4
    Conserved Domains (2) summary
    pfam07651
    Location:19 → 286
    ANTH; ANTH domain
    pfam08287
    Location:278 → 349
    DASH_Spc19; Spc19

  10. XM_068213528.1 → XP_068069629.1  phosphatidylinositol binding clathrin assembly protein b isoform X13

  11. XM_009291640.4 → XP_009289915.1  phosphatidylinositol binding clathrin assembly protein b isoform X11

    UniProtKB/TrEMBL
    A0A8M3APS6
    Conserved Domains (2) summary
    pfam07651
    Location:19 → 286
    ANTH; ANTH domain
    pfam08287
    Location:278 → 349
    DASH_Spc19; Spc19

  12. XM_009291639.4 → XP_009289914.1  phosphatidylinositol binding clathrin assembly protein b isoform X9

    UniProtKB/TrEMBL
    A0A8M3ASP1
    Conserved Domains (2) summary
    pfam07651
    Location:19 → 286
    ANTH; ANTH domain
    pfam08287
    Location:278 → 349
    DASH_Spc19; Spc19

  13. XM_017359236.3 → XP_017214725.1  phosphatidylinositol binding clathrin assembly protein b isoform X6

    UniProtKB/TrEMBL
    A0A8M6ZA05

  14. XM_009291638.4 → XP_009289913.1  phosphatidylinositol binding clathrin assembly protein b isoform X8

    UniProtKB/TrEMBL
    A0A8M3AIG6
    Conserved Domains (2) summary
    pfam07651
    Location:19 → 286
    ANTH; ANTH domain
    pfam08287
    Location:278 → 349
    DASH_Spc19; Spc19

  15. XM_017359235.3 → XP_017214724.1  phosphatidylinositol binding clathrin assembly protein b isoform X5

    UniProtKB/TrEMBL
    A0A8M6Z4D6

  16. XM_017359233.3 → XP_017214722.1  phosphatidylinositol binding clathrin assembly protein b isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z9M1

  17. XM_009291643.4 → XP_009289918.1  phosphatidylinositol binding clathrin assembly protein b isoform X17

    UniProtKB/TrEMBL
    A0A8M3AIH0
    Conserved Domains (2) summary
    pfam07651
    Location:19 → 282
    ANTH; ANTH domain
    pfam08287
    Location:265 → 344
    DASH_Spc19; Spc19
Nucleotide Protein Strain
Heading Accession and Version

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