fbxo5 F-box protein 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fbxo5provided by ZNC
Official Full Name: F-box protein 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4027
See related: Ensembl:ENSDARG00000039020 AllianceGenome:ZFIN:ZDB-GENE-030131-4027
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: emi1; fc65h02; wu:fc65h02; wu:fe06e07; wu:fz79f03; zgc:136397; zgc:158541
Summary: Predicted to enable ubiquitin ligase inhibitor activity. Acts upstream of or within several processes, including hemopoiesis; mitotic cytokinesis; and negative regulation of mitotic nuclear division. Predicted to be located in cytoplasm and spindle. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; blood; nervous system; optic vesicle; and segmental plate. Orthologous to human FBXO5 (F-box protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (46941930..46955155)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (46652095..46665320)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data indicate that emi1 deficiency-induced defects in vivo are due to the dysregulation of an APC/C-Cdh1 molecular axis.
Title: Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.
harpy/Rca1/emi1 has a role in patterning in the absence of cell division
Title: Characterization of harpy/Rca1/emi1 mutants: patterning in the absence of cell division.
Emi1 is a critical regulator of genomic fidelity during embryogenesis.
Title: Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.

Submit: New GeneRIF Correction

General gene information

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Markers

AW165253 (e-PCR)
- UniSTS:205870

fi43d04.x1 (e-PCR)
- UniSTS:197525

fc65h02.x1 (e-PCR)
- UniSTS:203982

Clone Names

MGC136397, MGC152677, MGC158541, MGC162839

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin ligase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of meiotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of meiotic nuclear division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of mitotic nuclear division	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: F-box only protein 5

Names: early mitotic inhibitor 1; harpy; harpy protein; hrp; rca1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.