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crbn cereblon [ Danio rerio (zebrafish) ]

Gene ID: 445491, updated on 28-Oct-2024

Summary

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Official Symbol
crbnprovided by ZNC
Official Full Name
cereblonprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040822-43
See related
Ensembl:ENSDARG00000054250 AllianceGenome:ZFIN:ZDB-GENE-040822-43
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92404
Summary
Predicted to enable metal ion binding activity. Involved in fin development; limb development; and otic vesicle development. Acts upstream of with a positive effect on cell population proliferation. Acts upstream of or within embryonic pectoral fin morphogenesis and otic vesicle morphogenesis. Part of ubiquitin ligase complex. Is expressed in several structures, including cranial vasculature; nervous system; notochord; otic vesicle; and radial glial cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 2. Orthologous to human CRBN (cereblon). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See crbn in Genome Data Viewer
Location:
chromosome: 6
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (40456798..40466838, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (40459262..40469291, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene TatD DNase domain containing 2 Neighboring gene von Hippel-Lindau tumor suppressor Neighboring gene zgc:152986 Neighboring gene FYVE, RhoGEF and PH domain containing 5b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Thalidomide targets EGFL6 to inhibit EGFL6/PAX6 axis-driven angiogenesis in small bowel vascular malformation. Tang CT, et al. Cell Mol Life Sci, 2020 Dec. PMID 32008086, Free PMC Article
  2. p63 is a cereblon substrate involved in thalidomide teratogenicity. Asatsuma-Okumura T, et al. Nat Chem Biol, 2019 Nov. PMID 31591562
  3. Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. Ando H, et al. iScience, 2019 May 31. PMID 31055217, Free PMC Article
  4. Identification of a primary target of thalidomide teratogenicity. Ito T, et al. Science, 2010 Mar 12. PMID 20223979
  5. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Shen C, et al. Nat Commun, 2021 Sep 6. PMID 34489457, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.
    Title: The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.
  2. Thalidomide targets EGFL6 to inhibit EGFL6/PAX6 axis-driven angiogenesis in small bowel vascular malformation.
    Title: Thalidomide targets EGFL6 to inhibit EGFL6/PAX6 axis-driven angiogenesis in small bowel vascular malformation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_positive_effect cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic pectoral fin morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fin development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in limb development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in otic vesicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within otic vesicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul4A-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4A-RING E3 ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein cereblon
Names
zcrbn

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003996.1 → NP_001003996.1  protein cereblon

    See identical proteins and their annotated locations for NP_001003996.1

    Status: PROVISIONAL

    Source sequence(s)
    BC080253
    UniProtKB/Swiss-Prot
    Q68EH9
    UniProtKB/TrEMBL
    B2GQH0
    Related
    ENSDARP00000062723.5, ENSDART00000062724.6
    Conserved Domains (3) summary
    cl19481
    Location:69 → 177
    LON; Found in ATP-dependent protease La (LON)
    cd15777
    Location:311 → 412
    CRBN_C_like; Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains
    pfam02190
    Location:68 → 307
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    40456798..40466838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476835.2 → XP_021332510.1  protein cereblon isoform X1

    UniProtKB/TrEMBL
    A0A8M9QFB5
    Conserved Domains (2) summary
    cd15777
    Location:326 → 383
    CRBN_C_like; Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains
    pfam02190
    Location:83 → 322
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68EH9.1 GenPept UniProtKB/Swiss-Prot:Q68EH9

Gene LinkOut

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