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st3gal8 ST3 beta-galactoside alpha-2,3-sialyltransferase 8 [ Danio rerio (zebrafish) ]

Gene ID: 445567, updated on 2-Nov-2024

Summary

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Official Symbol
st3gal8provided by ZNC
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-286
See related
Ensembl:ENSDARG00000007494 AllianceGenome:ZFIN:ZDB-GENE-050417-286
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
siat4; st3gal2l; zgc:111788
Summary
Predicted to enable beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Predicted to be involved in ganglioside biosynthetic process via lactosylceramide; protein glycosylation; and sialylation. Predicted to be located in Golgi cisterna membrane and extracellular region. Predicted to be active in membrane. Is expressed in several structures, including brain; cardiovascular system; paraxial mesoderm; pectoral fin; and pleuroperitoneal region. Orthologous to human C20orf173 (chromosome 20 open reading frame 173). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See st3gal8 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (26564541..26590419, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (26330873..26352830, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene fer-1 like family member 4 Neighboring gene un-named sa1614 Neighboring gene dynein, light chain, roadblock-type 1 Neighboring gene microtubule-associated protein 1 light chain 3 alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Vanbeselaere J, et al. J Proteome Res, 2012 Apr 6. PMID 22352757
  2. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Yamakawa N, et al. Nat Commun, 2018 Nov 7. PMID 30405127, Free PMC Article
  3. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article
  4. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC191931

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ganglioside biosynthetic process via lactosylceramide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ST3 beta-galactoside alpha-2,3-sialyltransferase 8
Names
ST3 beta-galactoside alpha-2,3-sialyltransferase 2, like
alpha 2,3-sialyltransferase ST3Gal I
st3gal2-r2
NP_001004017.1
XP_009304302.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004017.1 → NP_001004017.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 8 precursor

    See identical proteins and their annotated locations for NP_001004017.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ783740
    UniProtKB/TrEMBL
    Q6EV32
    Related
    ENSDARP00000008800.6, ENSDART00000002846.8
    Conserved Domains (1) summary
    pfam00777
    Location:89 → 341
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    26564541..26590419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306027.4 → XP_009304302.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AXN0, F1R1A7
    Related
    ENSDARP00000127954.1, ENSDART00000154349.3
    Conserved Domains (1) summary
    pfam00777
    Location:89 → 341
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_011017120.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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