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tmod2 tropomodulin 2 [ Danio rerio (zebrafish) ]

Gene ID: 447869, updated on 2-Nov-2024

Summary

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Official Symbol
tmod2provided by ZNC
Official Full Name
tropomodulin 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040912-185
See related
Ensembl:ENSDARG00000002571 AllianceGenome:ZFIN:ZDB-GENE-040912-185
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:86648
Summary
Predicted to enable tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Predicted to act upstream of or within pointed-end actin filament capping. Predicted to be active in striated muscle thin filament. Orthologous to several human genes including TMOD3 (tropomodulin 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See tmod2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (39327004..39386640)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (39346002..39401856)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 6 Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component Neighboring gene LysM, putative peptidoglycan-binding, domain containing 2 Neighboring gene secretogranin III

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts. Sullivan C, et al. PLoS One, 2017. PMID 28658311, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tropomyosin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tropomodulin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004608.1 → NP_001004608.1  tropomodulin-2

    See identical proteins and their annotated locations for NP_001004608.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081555
    UniProtKB/TrEMBL
    Q66I39
    Related
    ENSDARP00000018319.9, ENSDART00000012164.10
    Conserved Domains (2) summary
    cd00116
    Location:209 → 285
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:5 → 146
    Tropomodulin; Tropomodulin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    39327004..39386640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214761.1 → XP_068070862.1  tropomodulin-2 isoform X1

RNA

  1. XR_011007151.1 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395044.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    4552..24510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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