aqp8a.1 aquaporin 8a, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aqp8a.1provided by ZNC
Official Full Name: aquaporin 8a, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040912-106
See related: Ensembl:ENSDARG00000045141 AllianceGenome:ZFIN:ZDB-GENE-040912-106
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: aqp8; aqp8a; db04c12; mg:db04c12; zgc:103682
Summary: Enables urea transmembrane transporter activity and water transmembrane transporter activity. Acts upstream of or within urea transmembrane transport and water transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; eye; liver; mesoderm; and pleuroperitoneal region. Orthologous to human AQP8 (aquaporin 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (20366109..20373058, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (20244235..20251184, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these differential expression patterns of aqp8a.1, aqp8a.2, and aqp8b suggest that they possibly play distinct roles throughout the embryonic development by controlling or maintaining organ-specific cellular water homeostasis. Our study provides new evidence that organogenesis requires differential roles of Aqp8 proteins in zebrafish.
Title: Spatiotemporal expression pattern of the zebrafish aquaporin 8 family during early developmental stages.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables channel activity	IEA Inferred from Electronic Annotation more info
enables urea transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within urea transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within water transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aquaporin-8a.1

Names: aqp8aa; aquaporin 8; aquaporin-8aa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004661.1 → NP_001004661.1 aquaporin-8a.1

See identical proteins and their annotated locations for NP_001004661.1

Status: PROVISIONAL

Source sequence(s)

BC081511

UniProtKB/TrEMBL

B2GQQ7, Q66I64

Related

ENSDARP00000066381.5, ENSDART00000066382.6

Conserved Domains (1) summary

cl00200
Location:39 → 249

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...