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cpt1b carnitine palmitoyltransferase 1B (muscle) [ Danio rerio (zebrafish) ]

Gene ID: 449677, updated on 28-Oct-2024

Summary

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Official Symbol
cpt1bprovided by ZNC
Official Full Name
carnitine palmitoyltransferase 1B (muscle)provided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-9
See related
Ensembl:ENSDARG00000058285 AllianceGenome:ZFIN:ZDB-GENE-041010-9
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cpt1al; zgc:103709
Summary
Predicted to enable carnitine O-palmitoyltransferase activity. Acts upstream of or within energy homeostasis; response to (R)-carnitine; and response to bacterium. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adipose tissue; digestive system; eye; female organism; and integument. Orthologous to human CPT1B (carnitine palmitoyltransferase 1B). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See cpt1b in Genome Data Viewer
Location:
chromosome: 18
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (8346914..8367561)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (8388895..8409542)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene choline kinase beta Neighboring gene kelch repeat and BTB domain-containing protein 13 Neighboring gene selenophosphate synthetase 1 Neighboring gene BEN domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Alteration and the Function of Intestinal Microbiota in High-Fat-Diet- or Genetics-Induced Lipid Accumulation. Qiao F, et al. Front Microbiol, 2021. PMID 34603270, Free PMC Article
  2. Nonmonotonic response of type 2 diabetes by low concentration organochlorine pesticide mixture: Findings from multi-omics in zebrafish. Lee H, et al. J Hazard Mater, 2021 Aug 15. PMID 34492873
  3. In vivo imaging and genetic analysis link bacterial motility and symbiosis in the zebrafish gut. Rawls JF, et al. Proc Natl Acad Sci U S A, 2007 May 1. PMID 17456593, Free PMC Article
  4. The evolution of pepsinogen C genes in vertebrates: duplication, loss and functional diversification. Castro LF, et al. PLoS One, 2012. PMID 22427897, Free PMC Article
  5. Identification and Characterization of Carnitine Palmitoyltransferase 1 (cpt 1) Genes in Nile Tilapia, Oreochromis niloticus. Bayır M, et al. Evol Bioinform Online, 2020. PMID 32231427, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carnitine O-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carnitine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within energy homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to (R)-carnitine IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carnitine O-palmitoyltransferase 1, muscle isoform
Names
carnitine palmitoyltransferase 1A like
NP_001315121.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328192.1 → NP_001315121.1  carnitine O-palmitoyltransferase 1, muscle isoform

    Status: VALIDATED

    Source sequence(s)
    BX276107, CD605320, EH477141, EH509285
    UniProtKB/TrEMBL
    A0A8M1P3M1, F6P7Z9, Q1LXU0
    Related
    ENSDARP00000077856.5, ENSDART00000083421.7
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 760
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 46
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    8346914..8367561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001005940.1: Suppressed sequence

    Description
    NM_001005940.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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