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dut deoxyuridine triphosphatase [ Danio rerio (zebrafish) ]

Gene ID: 449835, updated on 2-Nov-2024

Summary

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Official Symbol
dutprovided by ZNC
Official Full Name
deoxyuridine triphosphataseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-93
See related
Ensembl:ENSDARG00000106529 AllianceGenome:ZFIN:ZDB-GENE-041010-93
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fa28d11; zgc:103772
Summary
Predicted to enable dUTP diphosphatase activity and magnesium ion binding activity. Predicted to be involved in dUMP biosynthetic process and dUTP catabolic process. Predicted to act upstream of or within nucleotide metabolic process. Is expressed in digestive system; nervous system; neural plate; pectoral fin; and tail bud. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dut in Genome Data Viewer
Location:
chromosome: 18
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (5308133..5314717)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_008805406.1 (437..4287)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene cortexin 2 Neighboring gene solute carrier family 12 member 1 Neighboring gene fibrillin 1 Neighboring gene SECIS binding protein 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Scrambled eggs: Proteomic portraits and novel biomarkers of egg quality in zebrafish (Danio rerio). Yilmaz O, et al. PLoS One, 2017. PMID 29145436, Free PMC Article
  2. Effects of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate on receptor-associated mRNA expression in zebrafish embryos/larvae. Liu C, et al. Aquat Toxicol, 2013 Mar 15. PMID 23306105
  3. fgf20 is essential for initiating zebrafish fin regeneration. Whitehead GG, et al. Science, 2005 Dec 23. PMID 16373575
  4. The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. Wu Y, et al. Chemosphere, 2017 Feb. PMID 27776230
  5. Differential modulation of expression of nuclear receptor mediated genes by tris(2-butoxyethyl) phosphate (TBOEP) on early life stages of zebrafish (Danio rerio). Ma Z, et al. Aquat Toxicol, 2015 Dec. PMID 26562049

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables dUTP diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dUTP diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dUMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dUMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dUMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dUTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dUTP catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Names
dUTP pyrophosphatase
NP_001006005.1
XP_021323312.1
XP_021323313.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006005.1 → NP_001006005.1  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

    See identical proteins and their annotated locations for NP_001006005.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083489
    UniProtKB/TrEMBL
    Q5XJ23
    Related
    ENSDARP00000156654.1, ENSDART00000179072.2
    Conserved Domains (1) summary
    cl00493
    Location:49 → 185
    trimeric_dUTPase; Trimeric dUTP diphosphatases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    5308133..5314717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467638.2 → XP_021323313.1  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8M9PA15
    Conserved Domains (1) summary
    cl00493
    Location:27 → 163
    trimeric_dUTPase; Trimeric dUTP diphosphatases

  2. XM_021467637.2 → XP_021323312.1  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8M9P120
    Conserved Domains (1) summary
    cl00493
    Location:30 → 166
    trimeric_dUTPase; Trimeric dUTP diphosphatases
Nucleotide Protein Strain
Heading Accession and Version

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