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MT-TD mitochondrially encoded tRNA aspartic acid [ Homo sapiens (human) ]

Gene ID: 4555, updated on 10-Oct-2023

Summary

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Official Symbol
MT-TDprovided by HGNC
Official Full Name
mitochondrially encoded tRNA aspartic acidprovided by HGNC
Primary source
HGNC:HGNC:7478
See related
MIM:590015; AllianceGenome:HGNC:7478
Gene type
tRNA
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTTD; TRND
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Genomic context

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Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) MT (non-nuclear) NC_012920.1 (7518..7585)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (7518..7585)

Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit I Neighboring gene tRNA-Ser Neighboring gene cytochrome c oxidase subunit II Neighboring gene tRNA-Lys

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A deafness-associated tRNAAsp mutation alters the m1G37 modification, aminoacylation and stability of tRNAAsp and mitochondrial function. Wang M, et al. Nucleic Acids Res, 2016 Dec 15. PMID 27536005, Free PMC Article
  2. Pathology-related mutation A7526G (A9G) helps in the understanding of the 3D structural core of human mitochondrial tRNA(Asp). Messmer M, et al. RNA, 2009 Aug. PMID 19535463, Free PMC Article
  3. Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk. Webb E, et al. Br J Cancer, 2008 Dec 16. PMID 19050702, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A deafness-associated m.7551A > G mutation in the mt-tRNAAsp gene reduced mitochondrial ATP production and increased the production of oxidative reactive species.
    Title: A deafness-associated tRNAAsp mutation alters the m1G37 modification, aminoacylation and stability of tRNAAsp and mitochondrial function.
  2. role of nucleotide 9 in the network of 3D tertiary interactions
    Title: Pathology-related mutation A7526G (A9G) helps in the understanding of the 3D structural core of human mitochondrial tRNA(Asp).
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

  • NAR: 0397

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases