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Dek Dek [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47906, updated on 2-Nov-2024

Summary

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Official Symbol
Dekprovided by FlyBase
Official Full Name
Dekprovided by FlyBase
Primary source
FLYBASE:FBgn0026533
Locus tag
Dmel_CG5935
See related
AllianceGenome:FB:FBgn0026533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0172774.191; anon-WO0172774.192; anon-WO0172774.194; CG593; CG5935; dDEK; dek; DEK; Dmel\CG5935; EG:EG0003.6; l(2)04154; l(2)k09907; lincRNA.S2954
Summary
Predicted to enable histone binding activity. Predicted to be involved in regulation of double-strand break repair. Located in nucleoplasm. Is expressed in adult brain cell body rind; adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to human DEK (DEK proto-oncogene). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Dek in Genome Data Viewer
Location:
53D14-53D14; 2-80 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16856220..16861738)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12743725..12749243)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44467 Neighboring gene Integrator 8 Neighboring gene Flap endonuclease 1 Neighboring gene ncRNA Neighboring gene P-element somatic inhibitor Neighboring gene eukaryotic translation elongation factor 1 beta Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. Kappes F, et al. Genes Dev, 2011 Apr 1. PMID 21460035, Free PMC Article
  2. REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. Gatfield D, et al. J Cell Biol, 2002 Nov 25. PMID 12438415, Free PMC Article
  3. Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. Gatfield D, et al. EMBO J, 2003 Aug 1. PMID 12881430, Free PMC Article
  4. The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila. Karres JS, et al. Cell, 2007 Oct 5. PMID 17923093
  5. Conservation and divergence of axon guidance mechanisms. Chisholm A, et al. Curr Opin Neurobiol, 1999 Oct. PMID 10508749

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dDEK facilitated H3.3 assembly during puff formation
    Title: A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Dek
Names
CG5935-PA
CG5935-PB
CG5935-PC
CG5935-PD
CG5935-PE
Dek-PA
Dek-PB
Dek-PC
Dek-PD
Dek-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16856220..16861738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274105.1 → NP_001261034.1  Dek, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261034.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAK4
    Conserved Domains (3) summary
    smart00513
    Location:282 → 316
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam06459
    Location:64 → 144
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08766
    Location:609 → 661
    DEK_C; DEK C terminal domain

  2. NM_166198.2 → NP_725621.1  Dek, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725621.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAK3
    Related
    FBpp0099857
    Conserved Domains (3) summary
    smart00513
    Location:286 → 320
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam06459
    Location:68 → 148
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08766
    Location:613 → 665
    DEK_C; DEK C terminal domain

  3. NM_166199.3 → NP_725622.2  Dek, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725622.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAK4
    Related
    FBpp0099855
    Conserved Domains (3) summary
    smart00513
    Location:282 → 316
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam06459
    Location:64 → 144
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08766
    Location:609 → 661
    DEK_C; DEK C terminal domain

  4. NM_206139.3 → NP_995861.2  Dek, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995861.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IFW6
    Conserved Domains (2) summary
    smart00513
    Location:282 → 316
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam06459
    Location:64 → 144
    RR_TM4-6; Ryanodine Receptor TM 4-6

  5. NM_143801.3 → NP_652058.1  Dek, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652058.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0D3
    Related
    FBpp0099856
    Conserved Domains (3) summary
    smart00513
    Location:288 → 322
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam06459
    Location:70 → 150
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08766
    Location:615 → 667
    DEK_C; DEK C terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZAK3 A1ZAK3
A1ZAK4 A1ZAK4
O96829 O96829
Q8IFW6 Q8IFW6
Q8T0D3 Q8T0D3

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