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pcdh2aa3 protocadherin 2 alpha a 3 [ Danio rerio (zebrafish) ]

Gene ID: 493597, updated on 28-Oct-2024

Summary

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Official Symbol
pcdh2aa3provided by ZNC
Official Full Name
protocadherin 2 alpha a 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-041118-14
See related
Ensembl:ENSDARG00000089874 AllianceGenome:ZFIN:ZDB-GENE-041118-14
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Pcdh2a10; DrPcdh2a10
Summary
Predicted to enable calcium ion binding activity. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See pcdh2aa3 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (2123123..2318590, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (2204772..2400239, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene protocadherin 2 gamma 12 Neighboring gene protocadherin 2 gamma 10 Neighboring gene protocadherin 2 gamma 13 Neighboring gene protocadherin 2 gamma 9 Neighboring gene protocadherin 2 gamma 8 Neighboring gene protocadherin 2 gamma 7 Neighboring gene protocadherin 2 gamma 6 Neighboring gene protocadherin 2 gamma 5 Neighboring gene protocadherin 2 gamma 2 Neighboring gene protocadherin 2 gamma 1 Neighboring gene protocadherin beta-15 Neighboring gene protocadherin 2 gamma 3 Neighboring gene protocadherin 2 alpha b 12 Neighboring gene protocadherin 2 alpha b 11 Neighboring gene protocadherin 2 alpha b 10 Neighboring gene protocadherin 2 alpha a 15 Neighboring gene protocadherin 2 alpha a 1 Neighboring gene protocadherin 2 alpha b 1 Neighboring gene protocadherin 2 alpha b2 Neighboring gene protocadherin 2 alpha b 5 Neighboring gene protocadherin 2 alpha b 8 Neighboring gene protocadherin 2 alpha b 9 Neighboring gene protocadherin 2 alpha b 3 Neighboring gene protocadherin 2 alpha c Neighboring gene protocadherin alpha-3-like Neighboring gene protocadherin gamma-A4-like Neighboring gene protocadherin beta-15-like Neighboring gene protocadherin alpha-3-like Neighboring gene protocadherin beta-15-like Neighboring gene protocadherin alpha-7-like Neighboring gene protocadherin alpha-3-like Neighboring gene protocadherin alpha-6-like Neighboring gene protocadherin gamma-A11-like Neighboring gene protocadherin gamma-A11-like Neighboring gene protocadherin gamma-A11-like Neighboring gene protocadherin alpha-3-like Neighboring gene protocadherin alpha-8-like Neighboring gene protocadherin alpha-3-like Neighboring gene si:ch73-233f7.7 Neighboring gene protocadherin alpha-C2-like Neighboring gene protocadherin alpha 8-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genomic organization and transcripts of the zebrafish Protocadherin genes. Tada MN, et al. Gene, 2004 Oct 13. PMID 15475161
  2. Gene conversion and the evolution of protocadherin gene cluster diversity. Noonan JP, et al. Genome Res, 2004 Mar. PMID 14993203, Free PMC Article
  3. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article
  4. Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes. Wu Q. Genetics, 2005 Apr. PMID 15744052, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protocadherin 2 alpha a 3
Names
pcdh2aa3-vCP
protocadherin 2 alpha 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009587.2 → NP_001009587.2  protocadherin 2 alpha a 3 precursor

    Status: VALIDATED

    Source sequence(s)
    CR847851, CT573264
    UniProtKB/TrEMBL
    Q60H66
    Related
    ENSDARP00000152672.1, ENSDART00000192735.1
    Conserved Domains (4) summary
    cd11304
    Location:247 → 347
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam15974
    Location:789 → 906
    Cadherin_tail; Cadherin C-terminal cytoplasmic tail, catenin-binding region
    pfam16492
    Location:692 → 746
    Cadherin_C_2; Cadherin cytoplasmic C-terminal
    cl09101
    Location:32 → 114
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    2123123..2318590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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