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lxn latexin [ Danio rerio (zebrafish) ]

Gene ID: 494053, updated on 18-Sep-2024

Summary

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Official Symbol
lxnprovided by ZNC
Official Full Name
latexinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041212-18
See related
Ensembl:ENSDARG00000043102 AllianceGenome:ZFIN:ZDB-GENE-041212-18
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
RARRES1; wu:fk66c02; zgc:103612
Summary
Predicted to enable metalloendopeptidase inhibitor activity. Predicted to be active in extracellular space. Orthologous to several human genes including LXN (latexin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See lxn in Genome Data Viewer
Location:
chromosome: 15
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (1181425..1199336, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (1220622..1238189, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2Y13 Neighboring gene myeloid leukemia factor 1 Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene major facilitator superfamily domain containing 1 Neighboring gene karyopherin alpha 4 (importin alpha 3) Neighboring gene schwannomin interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the α-tubulin tyrosination cycle. Sahab ZJ, et al. Cancer Res, 2011 Feb 15. PMID 21303978, Free PMC Article
  2. Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival. Maimouni S, et al. Oncotarget, 2019 Feb 26. PMID 30899431, Free PMC Article
  3. Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration. Cao J, et al. Development, 2016 Jan 15. PMID 26657776, Free PMC Article
  4. IGFBP1 increases β-cell regeneration by promoting α- to β-cell transdifferentiation. Lu J, et al. EMBO J, 2016 Sep 15. PMID 27516442, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
latexin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008596.1 → NP_001008596.1  latexin precursor

    See identical proteins and their annotated locations for NP_001008596.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086837
    UniProtKB/TrEMBL
    Q5PR40
    Related
    ENSDARP00000143725.1, ENSDART00000177869.2
    Conserved Domains (1) summary
    pfam06907
    Location:46 → 259
    Latexin; Latexin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    1181425..1199336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169638.4 → XP_005169695.1  latexin isoform X4

    UniProtKB/TrEMBL
    A0A8M2BGX5, F1RDP7
    Conserved Domains (1) summary
    pfam06907
    Location:8 → 220
    Latexin; Latexin

  2. XM_021481397.2 → XP_021337072.1  latexin isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q0C1
    Conserved Domains (1) summary
    pfam06907
    Location:46 → 257
    Latexin

  3. XM_005169637.4 → XP_005169694.1  latexin isoform X1

    UniProtKB/TrEMBL
    A0A286Y993, A0A8M2BGW6
    Conserved Domains (1) summary
    pfam06907
    Location:46 → 258
    Latexin; Latexin

  4. XM_068213540.1 → XP_068069641.1  latexin isoform X1

  5. XM_068213539.1 → XP_068069640.1  latexin isoform X1

  6. XM_021481398.2 → XP_021337073.1  latexin isoform X4

    UniProtKB/TrEMBL
    A0A8M2BGX5, F1RDP7
    Related
    ENSDARP00000063284.5, ENSDART00000063285.6
    Conserved Domains (1) summary
    pfam06907
    Location:8 → 220
    Latexin; Latexin

  7. XM_009291320.4 → XP_009289595.1  latexin isoform X3

    UniProtKB/TrEMBL
    A0A8M3ASB5
    Conserved Domains (1) summary
    pfam06907
    Location:19 → 231
    Latexin; Latexin
Nucleotide Protein Strain
Heading Accession and Version

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