dhtkd1 dehydrogenase E1 and transketolase domain containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dhtkd1provided by ZNC
Official Full Name: dehydrogenase E1 and transketolase domain containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041212-44
See related: Ensembl:ENSDARG00000016415 AllianceGenome:ZFIN:ZDB-GENE-041212-44
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: E1a; OADC-E1; OADH-E1; zgc:101818
Summary: Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity and thiamine pyrophosphate binding activity. Predicted to act upstream of or within glycolytic process and tricarboxylic acid cycle. Predicted to be located in mitochondrion. Is expressed in alar plate midbrain region; eye; immature eye; musculature system; and optic tectum. Human ortholog(s) of this gene implicated in 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth disease axonal type 2Q. Orthologous to human DHTKD1 (dehydrogenase E1 and transketolase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (8031999..8055229, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (7907907..7931137, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 2-oxoadipate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA Inferred from Electronic Annotation more info
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 2-oxoadipate dehydrogenase complex component E1

Names: 2-oxoadipate dehydrogenase, mitochondrial; alpha-KADH-E1; alpha-ketoadipate dehydrogenase; dehydrogenase E1 and transketolase domain-containing protein 1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

NP_001008619.1

EC 1.2.4.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008619.1 → NP_001008619.1 2-oxoadipate dehydrogenase complex component E1

See identical proteins and their annotated locations for NP_001008619.1

Status: PROVISIONAL

Source sequence(s)

BC086742

UniProtKB/Swiss-Prot

Q5PRA2

Related

ENSDARP00000025776.6, ENSDART00000003252.8

Conserved Domains (4) summary

PRK09404
Location:43 → 925

sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

cd02016
Location:182 → 455

TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...

pfam02779
Location:574 → 777

Transket_pyr; Transketolase, pyrimidine binding domain

pfam16870
Location:785 → 924

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal