ppih peptidylprolyl isomerase H (cyclophilin H) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppihprovided by ZNC
Official Full Name: peptidylprolyl isomerase H (cyclophilin H)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-127
See related: Ensembl:ENSDARG00000041530 AllianceGenome:ZFIN:ZDB-GENE-040625-127
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55766; zgc:86780; zgc:136730; zgc:158595
Summary: Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within angiogenesis. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human PPIH (peptidylprolyl isomerase H). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (47152704..47206399, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (47162238..47215933, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cyclosporin A binding	IBA Inferred from Biological aspect of Ancestor more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein peptidyl-prolyl isomerization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase H

NP_001009902.2

EC 5.2.1.8

NP_957499.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009902.2 → NP_001009902.2 peptidyl-prolyl cis-trans isomerase H isoform 1

See identical proteins and their annotated locations for NP_001009902.2

Status: PROVISIONAL

Source sequence(s)

BC114258

UniProtKB/TrEMBL

A0A8N7XJI6, F1R6Z6, F6PF84, Q6TLD7

Related

ENSDARP00000060876.3, ENSDART00000060877.5

Conserved Domains (1) summary

cl00197
Location:2 → 177

cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
NM_201205.1 → NP_957499.1 peptidyl-prolyl cis-trans isomerase H isoform 2

See identical proteins and their annotated locations for NP_957499.1

Status: PROVISIONAL

Source sequence(s)

BC045448

UniProtKB/TrEMBL

A0A8M1PFU0, Q7ZVQ9

Related

ENSDARP00000060882.4, ENSDART00000060883.6

Conserved Domains (1) summary

cd01926
Location:11 → 175

cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...