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Mtus2 microtubule associated scaffold protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498136, updated on 10-Jul-2024

Summary

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Official Symbol
Mtus2provided by RGD
Official Full Name
microtubule associated scaffold protein 2provided by RGD
Primary source
RGD:1562533
See related
EnsemblRapid:ENSRNOG00000032410 AllianceGenome:RGD:1562533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562533
Summary
Predicted to enable microtubule binding activity and protein homodimerization activity. Predicted to be active in nucleus. Predicted to colocalize with centrosome and cytoplasmic microtubule. Orthologous to human MTUS2 (microtubule associated scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 139.0), Brain (RPKM 38.5) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtus2 in Genome Data Viewer
Location:
12p11
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (11742713..12115798, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (6706531..7078331, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (8111655..8491553, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A, pseudogene 3 Neighboring gene solute carrier family 7 member 1 Neighboring gene uncharacterized LOC102547400 Neighboring gene uncharacterized LOC134481259 Neighboring gene U2 spliceosomal RNA Neighboring gene solute carrier family 46, member 3 Neighboring gene proteasome maturation protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CAZIP, a novel protein expressed in the developing heart and nervous system. Du Puy L, et al. Dev Dyn, 2009 Nov. PMID 19806667
  2. TIP150 interacts with and targets MCAK at the microtubule plus ends. Jiang K, et al. EMBO Rep, 2009 Aug. PMID 19543227, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microtubule-associated tumor suppressor candidate 2
Names
microtubule associated tumor suppressor candidate 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100989.3 → NP_001094459.2  microtubule-associated tumor suppressor candidate 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8J8YSZ5, A0JPQ3, F1LNR5
    Related
    ENSRNOP00000060535.3, ENSRNOT00000064721.4
    Conserved Domains (2) summary
    COG0419
    Location:22 → 285
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:155 → 279
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001374100.2 → NP_001361029.1  microtubule-associated tumor suppressor candidate 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A0G2K4U7
    Conserved Domains (2) summary
    PHA03247
    Location:624 → 1007
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:1021 → 1310
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    11742713..12115798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598434.3 → XP_017453923.1  microtubule-associated tumor suppressor candidate 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4U7
    Conserved Domains (2) summary
    PHA03247
    Location:624 → 1007
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:1021 → 1310
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

  2. XM_039089680.2 → XP_038945608.1  microtubule-associated tumor suppressor candidate 2 isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:13 → 220
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:183 → 487
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_039089681.2 → XP_038945609.1  microtubule-associated tumor suppressor candidate 2 isoform X4

    Conserved Domains (1) summary
    TIGR02168
    Location:57 → 361
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_039089682.2 → XP_038945610.1  microtubule-associated tumor suppressor candidate 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AJM3, A6K190
    Related
    ENSRNOP00000093232.1, ENSRNOT00000104730.2
    Conserved Domains (2) summary
    COG0419
    Location:22 → 318
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK11281
    Location:168 → 315
    PRK11281; mechanosensitive channel MscK

  5. XM_039089678.2 → XP_038945606.1  microtubule-associated tumor suppressor candidate 2 isoform X2

    Conserved Domains (1) summary
    PHA03247
    Location:729 → 993
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version

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