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Cnst consortin, connexin sorting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 498297, updated on 26-May-2024

Summary

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Symbol
Cnstprovided by RGD
Full Name
consortin, connexin sorting proteinprovided by RGD
Primary source
RGD:1564833
See related
Ensembl:ENSRNOG00000002710 AllianceGenome:RGD:1564833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564833
Summary
Predicted to enable connexin binding activity and phosphatase binding activity. Predicted to be involved in positive regulation of Golgi to plasma membrane protein transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane; trans-Golgi network; and transport vesicle. Orthologous to human CNST (consortin, connexin sorting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 196.4), Heart (RPKM 84.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cnst in Genome Data Viewer
Location:
13q26
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (93828694..93905497)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (91296740..91373531)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (97838325..97915131)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 3 Neighboring gene ribosomal protein L23,pseudogene 6 Neighboring gene uncharacterized LOC108352581 Neighboring gene transcription factor B2, mitochondrial Neighboring gene saccharopine dehydrogenase (putative) Neighboring gene kinesin family member 28, pseudogene Neighboring gene AT hook containing transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins. del Castillo FJ, et al. Hum Mol Genet, 2010 Jan 15. PMID 19864490, Free PMC Article
  2. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables connexin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables connexin binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
is_active_in transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
consortin; consortin, connexin sorting protein
Names
consortin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430792.1 → NP_001417721.1  consortin, connexin sorting protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  2. NM_001430793.1 → NP_001417722.1  consortin, connexin sorting protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    93828694..93905497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_573525.8 → XP_573525.5  consortin isoform X1

    See identical proteins and their annotated locations for XP_573525.5

    UniProtKB/TrEMBL
    A0A8I5ZKG8
    Related
    ENSRNOP00000078188.1
    Conserved Domains (1) summary
    pfam15281
    Location:673 → 784
    Consortin_C; Consortin C-terminus

  2. XM_039091465.2 → XP_038947393.1  consortin isoform X3

    UniProtKB/TrEMBL
    A6JGF5
    Conserved Domains (1) summary
    pfam15281
    Location:462 → 573
    Consortin_C; Consortin C-terminus

  3. XM_006250411.5 → XP_006250473.1  consortin isoform X2

    See identical proteins and their annotated locations for XP_006250473.1

    UniProtKB/TrEMBL
    D3ZKK3
    Related
    ENSRNOP00000003641.8
    Conserved Domains (1) summary
    pfam15281
    Location:608 → 719
    Consortin_C; Consortin C-terminus
Nucleotide Protein Strain
Heading Accession and Version

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