U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Klhl3 kelch-like family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498697, updated on 2-Nov-2024

Summary

Symbol
Klhl3provided by RGD
Full Name
kelch-like family member 3provided by RGD
Primary source
RGD:1565218
See related
EnsemblRapid:ENSRNOG00000019533 AllianceGenome:RGD:1565218
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565218
Summary
Predicted to enable cullin family protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including potassium ion homeostasis; protein K48-linked ubiquitination; and renal sodium ion absorption. Predicted to be located in cytoskeleton. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human KLHL3 (kelch like family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 97.4), Brain (RPKM 30.4) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Klhl3 in Genome Data Viewer
Location:
17p14
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (6528114..6651338)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (6523089..6645971)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (6924423..7029374)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482668 Neighboring gene uncharacterized LOC108348619 Neighboring gene heterogeneous nuclear ribonucleoprotein A0 Neighboring gene uncharacterized LOC134482666 Neighboring gene microRNA 874 Neighboring gene sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene uncharacterized LOC120097735

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables cullin family protein binding IEA
Inferred from Electronic Annotation
more info
 
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-like ligase-substrate adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in distal tubule morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in distal tubule morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in distal tubule morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in potassium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in renal absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in renal sodium ion absorption IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in renal sodium ion absorption IEA
Inferred from Electronic Annotation
more info
 
involved_in renal sodium ion absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in renal sodium ion absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul3-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
kelch-like protein 3
Names
kelch-like 3
kelch-like protein 3-like

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419643.1NP_001406572.1  kelch-like protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    Related
    ENSRNOP00000081756.2, ENSRNOT00000119182.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    6528114..6651338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096443.2XP_038952371.1  kelch-like protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G8D9
    Conserved Domains (4) summary
    PHA03098
    Location:24540
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:405450
    Kelch; KELCH repeat [structural motif]
    cd18513
    Location:121250
    BACK_KLHL3; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3)
    cl38908
    Location:16123
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
  2. XM_039096444.2XP_038952372.1  kelch-like protein 3 isoform X2

    Conserved Domains (4) summary
    PHA03098
    Location:88335
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:200245
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:59103
    Kelch_1; Kelch motif
    cl28903
    Location:145
    BACK; BACK (BTB and C-terminal Kelch) domain
  3. XM_039096445.2XP_038952373.1  kelch-like protein 3 isoform X3

    Conserved Domains (3) summary
    PHA03098
    Location:47294
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:159204
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:1862
    Kelch_1; Kelch motif