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Gas2 growth arrest-specific 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499156, updated on 2-Nov-2024

Summary

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Official Symbol
Gas2provided by RGD
Official Full Name
growth arrest-specific 2provided by RGD
Primary source
RGD:1563167
See related
AllianceGenome:RGD:1563167
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563167
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin crosslink formation. Predicted to act upstream of or within several processes, including ovarian follicle development; ovulation; and regulation of Notch signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in actin filament. Orthologous to human GAS2 (growth arrest specific 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 207.5), Adrenal (RPKM 34.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gas2 in Genome Data Viewer
Location:
1q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (110587952..110721572)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (101452361..101582619)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (107234389..107363624)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099815 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene FA complementation group F Neighboring gene small VCP interacting protein Neighboring gene coiled-coil domain containing 179

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Growth Arrest Specific 2 (GAS2) is a Critical Mediator of Germ Cell Cyst Breakdown and Folliculogenesis in Mice. York JP, et al. Sci Rep, 2016 Oct 13. PMID 27734842, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antral ovarian follicle growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within basement membrane organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within initiation of primordial ovarian follicle growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ovulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
growth arrest-specific protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127504.1 → NP_001120976.1  growth arrest-specific protein 2

    See identical proteins and their annotated locations for NP_001120976.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JBH5, A6JBH6, G3V857
    Conserved Domains (2) summary
    smart00243
    Location:201 → 274
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd00014
    Location:36 → 158
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    110587952..110721572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589558.3 → XP_017445047.1  growth arrest-specific protein 2 isoform X1

    Conserved Domains (2) summary
    cd00014
    Location:36 → 158
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl02524
    Location:201 → 292
    GAS2; Growth-Arrest-Specific Protein 2 Domain

  2. XM_063271101.1 → XP_063127171.1  growth arrest-specific protein 2 isoform X2

    UniProtKB/TrEMBL
    A6JBH5, G3V857

  3. XM_063271078.1 → XP_063127148.1  growth arrest-specific protein 2 isoform X1

  4. XM_039087544.2 → XP_038943472.1  growth arrest-specific protein 2 isoform X3

    Conserved Domains (1) summary
    cl00030
    Location:30 → 158
    CH_SF; calponin homology (CH) domain superfamily

  5. XM_017589559.3 → XP_017445048.1  growth arrest-specific protein 2 isoform X2

    UniProtKB/TrEMBL
    A6JBH5, A6JBH6, G3V857
    Conserved Domains (2) summary
    smart00243
    Location:201 → 274
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd00014
    Location:36 → 158
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  6. XM_063271093.1 → XP_063127163.1  growth arrest-specific protein 2 isoform X2

    UniProtKB/TrEMBL
    A6JBH5, G3V857

  7. XM_063271070.1 → XP_063127140.1  growth arrest-specific protein 2 isoform X1

  8. XM_063271086.1 → XP_063127156.1  growth arrest-specific protein 2 isoform X2

    UniProtKB/TrEMBL
    A6JBH5, G3V857

  9. XM_063271105.1 → XP_063127175.1  growth arrest-specific protein 2 isoform X2

    UniProtKB/TrEMBL
    A6JBH5, G3V857

  10. XM_063271079.1 → XP_063127149.1  growth arrest-specific protein 2 isoform X1

  11. XM_063271067.1 → XP_063127137.1  growth arrest-specific protein 2 isoform X1

  12. XM_063271089.1 → XP_063127159.1  growth arrest-specific protein 2 isoform X2

    UniProtKB/TrEMBL
    A6JBH5, G3V857

  13. XM_006229273.5 → XP_006229335.1  growth arrest-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006229335.1

    Conserved Domains (2) summary
    cd00014
    Location:36 → 158
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl02524
    Location:201 → 292
    GAS2; Growth-Arrest-Specific Protein 2 Domain
Nucleotide Protein Strain
Heading Accession and Version

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