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Gemin7 gem (nuclear organelle) associated protein 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499391, updated on 2-Nov-2024

Summary

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Official Symbol
Gemin7provided by RGD
Official Full Name
gem (nuclear organelle) associated protein 7provided by RGD
Primary source
RGD:1597035
See related
EnsemblRapid:ENSRNOG00000049772 AllianceGenome:RGD:1597035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in Gemini of coiled bodies and cytosol. Predicted to be part of SMN complex. Orthologous to human GEMIN7 (gem nuclear organelle associated protein 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 30.9), Muscle (RPKM 30.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gemin7 in Genome Data Viewer
Location:
1q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88343032..88352473, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (79215054..79228769, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80473966..80487976, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene NTPase, KAP family P-loop domain containing 1 Neighboring gene protein phosphatase 1, regulatory subunit 37 Neighboring gene zinc finger protein 296 Neighboring gene CLK4-associating serine/arginine rich protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. Baccon J, et al. J Biol Chem, 2002 Aug 30. PMID 12065586
  2. Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis. Yong J, et al. Mol Cell, 2010 May 28. PMID 20513430, Free PMC Article
  3. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Chari A, et al. Cell, 2008 Oct 31. PMID 18984161
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Gemini of coiled bodies ISO
Inferred from Sequence Orthology
more info
  
part_of SMN complex ISO
Inferred from Sequence Orthology
more info
  
part_of SMN-Sm protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of Sm-like protein family complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gem-associated protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109170.1 → NP_001102640.1  gem-associated protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001102640.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473979
    UniProtKB/TrEMBL
    A6J8P9, M0R5G2
    Conserved Domains (1) summary
    cd11677
    Location:66 → 142
    Gemin7; Gemin 7

  2. NM_001430430.1 → NP_001417359.1  gem-associated protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AGJ9, A6J8Q0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    88343032..88352473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228461.5 → XP_006228523.1  gem-associated protein 7 isoform X2

    Related
    ENSRNOP00000092860.1, ENSRNOT00000100949.2
    Conserved Domains (2) summary
    cd11677
    Location:52 → 128
    Gemin7; Gemin 7
    pfam12901
    Location:10 → 27
    SUZ-C; SUZ-C motif

  2. XM_039088190.2 → XP_038944118.1  gem-associated protein 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AGJ9, A6J8Q0
    Related
    ENSRNOP00000095884.1, ENSRNOT00000102935.2
    Conserved Domains (2) summary
    cd11677
    Location:52 → 128
    Gemin7; Gemin 7
    pfam12901
    Location:10 → 27
    SUZ-C; SUZ-C motif

  3. XM_017589594.3 → XP_017445083.1  gem-associated protein 7 isoform X1

    Related
    ENSRNOP00000098839.1, ENSRNOT00000128210.1
    Conserved Domains (1) summary
    cd11677
    Location:68 → 144
    Gemin7; Gemin 7
Nucleotide Protein Strain
Heading Accession and Version

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