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Asb12 ankyrin repeat and SOCS box-containing 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 503446, updated on 28-Oct-2024

Summary

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Official Symbol
Asb12provided by RGD
Official Full Name
ankyrin repeat and SOCS box-containing 12provided by RGD
Primary source
RGD:1561142
See related
EnsemblRapid:ENSRNOG00000004197 AllianceGenome:RGD:1561142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB12 (ankyrin repeat and SOCS box containing 12). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Muscle (RPKM 407.6) and Heart (RPKM 113.7) See more
Orthologs
human mouse all
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Genomic context

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See Asb12 in Genome Data Viewer
Location:
Xq22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (64338223..64487615, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (60328325..60478031, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (64714337..64800662, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P1 like 2 Neighboring gene APC membrane recruitment protein 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A3-like Neighboring gene ribosomal protein SA, pseudogene 14 Neighboring gene profilin-2-like Neighboring gene zinc finger C4H2-type containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. Kohroki J, et al. FEBS Lett, 2005 Dec 19. PMID 16325183
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC125221

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 12
Names
ankyrin repeat and SOCS box-containing protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037367.1 → NP_001032444.1  ankyrin repeat and SOCS box protein 12

    See identical proteins and their annotated locations for NP_001032444.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107911
    UniProtKB/TrEMBL
    F6RJR3, Q32Q00
    Conserved Domains (4) summary
    sd00045
    Location:66 → 94
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:175 → 199
    Ank; Ankyrin repeat
    pfam07525
    Location:268 → 306
    SOCS_box; SOCS box
    pfam12796
    Location:68 → 159
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001434359.1 → NP_001421288.1  ankyrin repeat and SOCS box protein 12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  3. NM_001434360.1 → NP_001421289.1  ankyrin repeat and SOCS box protein 12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    64338223..64487615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099991.2 → XP_038955919.1  ankyrin repeat and SOCS box protein 12 isoform X1

    UniProtKB/TrEMBL
    F6RJR3, Q32Q00
    Conserved Domains (4) summary
    sd00045
    Location:66 → 94
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:175 → 199
    Ank; Ankyrin repeat
    pfam07525
    Location:268 → 306
    SOCS_box; SOCS box
    pfam12796
    Location:68 → 159
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_063280265.1 → XP_063136335.1  ankyrin repeat and SOCS box protein 12 isoform X1

    UniProtKB/TrEMBL
    F6RJR3, Q32Q00
    Related
    ENSRNOP00000005663.4, ENSRNOT00000005663.8

  3. XM_006257044.5 → XP_006257106.1  ankyrin repeat and SOCS box protein 12 isoform X1

    UniProtKB/TrEMBL
    F6RJR3, Q32Q00
    Conserved Domains (4) summary
    sd00045
    Location:66 → 94
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:175 → 199
    Ank; Ankyrin repeat
    pfam07525
    Location:268 → 306
    SOCS_box; SOCS box
    pfam12796
    Location:68 → 159
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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