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Tmod3 tropomodulin 3 [ Mus musculus (house mouse) ]

Gene ID: 50875, updated on 2-Nov-2024

Summary

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Official Symbol
Tmod3provided by MGI
Official Full Name
tropomodulin 3provided by MGI
Primary source
MGI:MGI:1355315
See related
Ensembl:ENSMUSG00000058587 AllianceGenome:MGI:1355315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UTMOD; U-Tmod
Summary
Enables tropomyosin binding activity. Acts upstream of or within actin cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Located in striated muscle thin filament. Is expressed in several structures, including alimentary system; brain; heart; metanephros; and sensory organ. Orthologous to human TMOD3 (tropomodulin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 9.7), placenta adult (RPKM 7.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmod3 in Genome Data Viewer
Location:
9 D; 9 42.3 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75405066..75466939, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75497784..75559657, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Leo1, Paf1/RNA polymerase II complex component Neighboring gene STARR-seq mESC enhancer starr_24669 Neighboring gene predicted gene, 57538 Neighboring gene predicted gene 7972 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75407347-75407647 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75429888-75430189 Neighboring gene tropomodulin 2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75478519-75478819 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton. Ghosh A, et al. FASEB J, 2022 Mar. PMID 35195928
  2. Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia. Stobdan T, et al. Hum Mol Genet, 2022 Mar 31. PMID 34718575, Free PMC Article
  3. Tropomodulin-3 is essential in asymmetric division during mouse oocyte maturation. Jo YJ, et al. Sci Rep, 2016 Jul 4. PMID 27374327, Free PMC Article
  4. Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis. Sui Z, et al. Blood, 2015 Jul 23. PMID 25964668, Free PMC Article
  5. Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton. Moyer JD, et al. Blood, 2010 Oct 7. PMID 20585041, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia.
    Title: Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia.
  2. Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton.
    Title: Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton.
  3. Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts.
    Title: Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts.
  4. Tmod3 plays crucial roles in oocyte maturation
    Title: Tropomodulin-3 is essential in asymmetric division during mouse oocyte maturation.
  5. Tmod3 is a novel Akt2 effector that mediates insulin-induced cortical actin remodelling and subsequent GLUT4 membrane insertion
    Title: Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling.
  6. Loss of TMOD3 is associated with hemorrhage, defect in actin polymerization, organization and platelet biogenesis.
    Title: Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis.
  7. Tmod1 and Tmod3 showed somewhat different tropomyosin-binding site utilization.
    Title: Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3.
  8. Tmod3-/- embryos are defective in definitive erythropoiesis with reduced progenitors, impaired terminal differentiation, and enucleation.
    Title: Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver.
  9. Western blots of Tmod1-null RBCs confirm the absence of Tmod1 and show the presence of Tmod3, which is normally not present in RBCs.
    Title: Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton.
  10. Tmod3 and -4 localize to pointed ends in Tmod1-null adult muscle
    Title: Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule minus-end binding ISO
Inferred from Sequence Orthology
more info
  
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tropomyosin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell motility ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within erythrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pointed-end actin filament capping ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  
is_active_in striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in striated muscle thin filament IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tropomodulin-3
Names
tropomodulin 3; ubiquitous tropomodulin
ubiquitous tropomodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357828.1 → NP_001344757.1  tropomodulin-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC115880, AC123832
    UniProtKB/TrEMBL
    Q8C3Z3
    Conserved Domains (1) summary
    cl26161
    Location:60 → 172
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. NM_016963.2 → NP_058659.1  tropomodulin-3 isoform 1

    See identical proteins and their annotated locations for NP_058659.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF237630, AK147017, BY067594
    Consensus CDS
    CCDS23344.1
    UniProtKB/Swiss-Prot
    Q3TIT1, Q9JHJ0
    UniProtKB/TrEMBL
    Q3TFA9
    Related
    ENSMUSP00000072087.8, ENSMUST00000072232.9
    Conserved Domains (2) summary
    cd00116
    Location:199 → 311
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:5 → 144
    Tropomodulin; Tropomodulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    75405066..75466939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHJ0.1 GenPept UniProtKB/Swiss-Prot:Q9JHJ0

Gene LinkOut

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