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CDK14 cyclin dependent kinase 14 [ Homo sapiens (human) ]

Gene ID: 5218, updated on 2-Nov-2024

Summary

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Official Symbol
CDK14provided by HGNC
Official Full Name
cyclin dependent kinase 14provided by HGNC
Primary source
HGNC:HGNC:8883
See related
Ensembl:ENSG00000058091 MIM:610679; AllianceGenome:HGNC:8883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PFTK1; PFTAIRE1
Summary
Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in G2/M transition of mitotic cell cycle and regulation of canonical Wnt signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 6.5), kidney (RPKM 3.1) and 24 other tissues See more
Orthologs
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Genomic context

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See CDK14 in Genome Data Viewer
Location:
7q21.13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (90596321..91210590)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (91844591..92458441)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (90225635..90839905)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:90032955-90033480 Neighboring gene Sharpr-MPRA regulatory region 3343 Neighboring gene Sharpr-MPRA regulatory region 14602 Neighboring gene claudin 12 Neighboring gene uncharacterized LOC124901693 Neighboring gene PTTG1IP family member 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:90208498-90209697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26246 Neighboring gene small nucleolar RNA U13 Neighboring gene MPRA-validated peak6628 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26247 Neighboring gene TVP23C pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26251 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:90395797-90396298 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:90394025-90394596 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:90396299-90396798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26252 Neighboring gene uncharacterized LOC124901694 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:90661021-90661555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:90690954-90691454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:90691455-90691955 Neighboring gene VISTA enhancer hs1627 Neighboring gene VISTA enhancer hs1628 Neighboring gene VISTA enhancer hs1633 Neighboring gene PTP4A1 pseudogene 3 Neighboring gene VISTA enhancer hs1631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18363 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18364 Neighboring gene uncharacterized LOC124901695 Neighboring gene frizzled class receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Knockdown of PFTK1 Expression by RNAi Inhibits the Proliferation and Invasion of Human Non-Small Lung Adenocarcinoma Cells. Liu MH, et al. Oncol Res, 2016. PMID 27458099, Free PMC Article
  2. Upregulated PFTK1 promotes tumor cell proliferation, migration, and invasion in breast cancer. Gu X, et al. Med Oncol, 2015 Jul. PMID 26033031
  3. Knockdown of PFTK1 Inhibits the Migration of Glioma Cells. Fan S, et al. J Mol Neurosci, 2015 Oct. PMID 26234562
  4. Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus-Related Hepatocellular Carcinoma. Li Y, et al. Clin Cancer Res, 2018 Feb 15. PMID 29246937
  5. PFTK1 Promotes Gastric Cancer Progression by Regulating Proliferation, Migration and Invasion. Yang L, et al. PLoS One, 2015. PMID 26488471, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N6-methyladenosine-modified circCDK14 promotes ossification of the ligamentum flavum via epigenetic modulation by targeting AFF4.
    Title: N6-methyladenosine-modified circCDK14 promotes ossification of the ligamentum flavum via epigenetic modulation by targeting AFF4.
  2. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
    Title: Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
  3. P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC.
    Title: P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC.
  4. LncRNA NORAD accelerates the progression of non-small cell lung cancer via targeting miRNA-455/CDK14 axis.
    Title: LncRNA NORAD accelerates the progression of non-small cell lung cancer via targeting miRNA-455/CDK14 axis.
  5. CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA.
    Title: CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA.
  6. Depletion of circRNA circ_CDK14 inhibits osteosarcoma progression by regulating the miR-520a-3p/GAB1 axis.
    Title: Depletion of circRNA circ_CDK14 inhibits osteosarcoma progression by regulating the miR-520a-3p/GAB1 axis.
  7. MiR-205 Inhibits Sporadic Vestibular Schwannoma Cell Proliferation by Targeting Cyclin-Dependent Kinase 14.
    Title: MiR-205 Inhibits Sporadic Vestibular Schwannoma Cell Proliferation by Targeting Cyclin-Dependent Kinase 14.
  8. CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2.
    Title: CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2.
  9. Upregulation of miR-1825 inhibits the progression of glioblastoma by suppressing CDK14 though Wnt/beta-catenin signaling pathway.
    Title: Upregulation of miR-1825 inhibits the progression of glioblastoma by suppressing CDK14 though Wnt/β-catenin signaling pathway.
  10. we demonstrated that MSC-AS1/miR-29b-3p axis modulates the cell proliferation and GEM-induced cell apoptosis in PDAC cell lines through CDK14. We provided a novel experimental basis for PDAC treatment from the perspective of lncRNA-miRNA-mRNA network.
    Title: The role of lncRNA MSC-AS1/miR-29b-3p axis-mediated CDK14 modulation in pancreatic cancer proliferation and Gemcitabine-induced apoptosis.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat specifically associates with CDK14 promoter to upregulate CDK14 expression in T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0834

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent kinase 14
Names
PFTAIRE protein kinase 1
cell division protein kinase 14
serine/threonine-protein kinase PFTAIRE-1
NP_001274064.1
NP_001274065.1
NP_001274066.1
NP_036527.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287135.2 → NP_001274064.1  cyclin-dependent kinase 14 isoform a

    See identical proteins and their annotated locations for NP_001274064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB020641, AC002456, AF119833, AK297974, BC136477, BC152436, BM740394, BP336072, DB476188, DC420282, HY179664
    Consensus CDS
    CCDS75626.1
    UniProtKB/Swiss-Prot
    A4D1E6, A6NK51, A8WFP6, B4DHG5, B4DNM2, O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0
    Related
    ENSP00000369390.3, ENST00000380050.8
    Conserved Domains (1) summary
    cd07869
    Location:129 → 431
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

  2. NM_001287136.1 → NP_001274065.1  cyclin-dependent kinase 14 isoform c

    See identical proteins and their annotated locations for NP_001274065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AB020641, AK295086, AK316026, BC136477, BC152436, BM740394, BP336072, DB476188, DC325068
    Consensus CDS
    CCDS75627.1
    UniProtKB/Swiss-Prot
    O94921
    Related
    ENSP00000385034.1, ENST00000406263.5
    Conserved Domains (1) summary
    cd07869
    Location:83 → 385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

  3. NM_001287137.1 → NP_001274066.1  cyclin-dependent kinase 14 isoform d

    See identical proteins and their annotated locations for NP_001274066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AB020641, AK296406, AK316026, BC136477, BC152436, BM740394, BP336072, DB476188, DC325068
    Consensus CDS
    CCDS75628.1
    UniProtKB/TrEMBL
    B4DK59, E7EUK8
    Related
    ENSP00000398936.2, ENST00000436577.3
    Conserved Domains (1) summary
    cl21453
    Location:25 → 302
    PKc_like; Protein Kinases, catalytic domain

  4. NM_012395.3 → NP_036527.1  cyclin-dependent kinase 14 isoform b

    See identical proteins and their annotated locations for NP_036527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AB020641, BC136477, BC152436, BM740394, BP336072, DB476188
    Consensus CDS
    CCDS5619.1
    UniProtKB/Swiss-Prot
    O94921
    Related
    ENSP00000265741.3, ENST00000265741.7
    Conserved Domains (2) summary
    cd07869
    Location:111 → 413
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
    PLN00009
    Location:115 → 404
    PLN00009; cyclin-dependent kinase A; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    90596321..91210590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    91844591..92458441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94921.3 GenPept UniProtKB/Swiss-Prot:O94921

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools