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Ankzf1 ankyrin repeat and zinc finger domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 52231, updated on 2-Nov-2024

Summary

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Official Symbol
Ankzf1provided by MGI
Official Full Name
ankyrin repeat and zinc finger domain containing 1provided by MGI
Primary source
MGI:MGI:1098746
See related
Ensembl:ENSMUSG00000026199 AllianceGenome:MGI:1098746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1Ertd161e; 1300008P06Rik; 2810025E10Rik
Summary
Predicted to enable RNA endonuclease activity and catalytic activity, acting on a tRNA. Predicted to be involved in cellular response to hydrogen peroxide; proteolysis involved in protein catabolic process; and rescue of stalled ribosome. Predicted to be located in cytoplasm. Is expressed in genitourinary system. Orthologous to human ANKZF1 (ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 15.3), kidney adult (RPKM 12.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ankzf1 in Genome Data Viewer
Location:
1 C4; 1 38.62 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75168794..75176031)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75192160..75199387)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B member 6 Neighboring gene STARR-positive B cell enhancer ABC_E8982 Neighboring gene autophagy related 9A Neighboring gene STARR-positive B cell enhancer ABC_E321 Neighboring gene galactosidase, beta 1-like Neighboring gene serine/threonine kinase 16 Neighboring gene STARR-positive B cell enhancer ABC_E3282 Neighboring gene tubulin, alpha 4A Neighboring gene RIKEN cDNA A630095N17 gene Neighboring gene STARR-seq mESC enhancer starr_01353

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NAT10-mediated ac(4)C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1. Miao D, et al. Cancer Commun (Lond), 2024 Mar. PMID 38407929, Free PMC Article
  2. A stress-responsive system for mitochondrial protein degradation. Heo JM, et al. Mol Cell, 2010 Nov 12. PMID 21070972, Free PMC Article
  3. Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Ling KH, et al. Genome Biol, 2009. PMID 19799774, Free PMC Article
  4. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
  5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NAT10-mediated ac[4]C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1.
    Title: NAT10-mediated ac(4)C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA endonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity, acting on a tRNA ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity, acting on a tRNA ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
Inferred from Sequence Orthology
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tRNA endonuclease ANKZF1
Names
ankyrin repeat and zinc finger domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267620.1 → NP_001254549.1  tRNA endonuclease ANKZF1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 3' exons but includes an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AI425962, BC051449, CN717456
    Conserved Domains (2) summary
    smart00451
    Location:93 → 127
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:98 → 120
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001404903.1 → NP_001391832.1  tRNA endonuclease ANKZF1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  3. NM_001404904.1 → NP_001391833.1  tRNA endonuclease ANKZF1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  4. NM_001404905.1 → NP_001391834.1  tRNA endonuclease ANKZF1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  5. NM_001404906.1 → NP_001391835.1  tRNA endonuclease ANKZF1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  6. NM_001404907.1 → NP_001391836.1  tRNA endonuclease ANKZF1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  7. NM_026187.5 → NP_080463.3  tRNA endonuclease ANKZF1 isoform 1

    See identical proteins and their annotated locations for NP_080463.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC166150, AW536302, BU054541, BU755641, CN717456, CX232548, DV062487
    Consensus CDS
    CCDS56632.1
    UniProtKB/Swiss-Prot
    B9EKG0, Q80UU1, Q9CZF5
    UniProtKB/TrEMBL
    J3QM81
    Related
    ENSMUSP00000136163.2, ENSMUST00000152233.9
    Conserved Domains (4) summary
    cd00204
    Location:520 → 600
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00020
    Location:98 → 120
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12796
    Location:520 → 587
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:556 → 587
    ANK; ANK repeat [structural motif]

RNA

  1. NR_051998.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC166150, BU755641, CN717456
    Related
    ENSMUST00000145459.9

  2. NR_051999.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region and several exons in the 3' region, but includes an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI425962, AK084573, CN717456
    Related
    ENSMUST00000134378.9

  3. NR_175880.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  4. NR_175881.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  5. NR_175882.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  6. NR_175883.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  7. NR_175884.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  8. NR_175885.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  9. NR_175886.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  10. NR_175887.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

  11. NR_175888.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166150, FQ976561

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75168794..75176031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496507.2 → XP_006496570.1  tRNA endonuclease ANKZF1 isoform X1

    UniProtKB/Swiss-Prot
    B9EKG0, Q80UU1, Q9CZF5
    Conserved Domains (7) summary
    PTZ00322
    Location:557 → 629
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00020
    Location:98 → 120
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00045
    Location:556 → 587
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:557 → 587
    Ank; Ankyrin repeat
    pfam12796
    Location:520 → 587
    Ank_2; Ankyrin repeats (3 copies)
    pfam18716
    Location:773 → 813
    VATC; Vms1-associating treble clef domain
    pfam18826
    Location:231 → 375
    bVLRF1; bacteroidetes VLRF1 release factor

  2. XM_036152358.1 → XP_036008251.1  tRNA endonuclease ANKZF1 isoform X4

    Conserved Domains (6) summary
    PTZ00322
    Location:264 → 336
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:263 → 294
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:264 → 294
    Ank; Ankyrin repeat
    pfam12796
    Location:227 → 294
    Ank_2; Ankyrin repeats (3 copies)
    pfam18716
    Location:416 → 453
    VATC; Vms1-associating treble clef domain
    pfam18826
    Location:1 → 82
    bVLRF1; bacteroidetes VLRF1 release factor

  3. XM_036152357.1 → XP_036008250.1  tRNA endonuclease ANKZF1 isoform X2

    Conserved Domains (6) summary
    PTZ00322
    Location:323 → 395
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:322 → 353
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:323 → 353
    Ank; Ankyrin repeat
    pfam12796
    Location:286 → 353
    Ank_2; Ankyrin repeats (3 copies)
    pfam18716
    Location:539 → 578
    VATC; Vms1-associating treble clef domain
    pfam18826
    Location:1 → 141
    bVLRF1; bacteroidetes VLRF1 release factor

  4. XM_011238696.2 → XP_011236998.1  tRNA endonuclease ANKZF1 isoform X2

    See identical proteins and their annotated locations for XP_011236998.1

    Conserved Domains (6) summary
    PTZ00322
    Location:323 → 395
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:322 → 353
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:323 → 353
    Ank; Ankyrin repeat
    pfam12796
    Location:286 → 353
    Ank_2; Ankyrin repeats (3 copies)
    pfam18716
    Location:539 → 578
    VATC; Vms1-associating treble clef domain
    pfam18826
    Location:1 → 141
    bVLRF1; bacteroidetes VLRF1 release factor

  5. XM_030255491.1 → XP_030111351.1  tRNA endonuclease ANKZF1 isoform X3

    Conserved Domains (6) summary
    PTZ00322
    Location:264 → 336
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:263 → 294
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:264 → 294
    Ank; Ankyrin repeat
    pfam12796
    Location:227 → 294
    Ank_2; Ankyrin repeats (3 copies)
    pfam18716
    Location:480 → 520
    VATC; Vms1-associating treble clef domain
    pfam18826
    Location:1 → 82
    bVLRF1; bacteroidetes VLRF1 release factor

  6. XM_036152354.1 → XP_036008247.1  tRNA endonuclease ANKZF1 isoform X2

    Conserved Domains (6) summary
    PTZ00322
    Location:323 → 395
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:322 → 353
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:323 → 353
    Ank; Ankyrin repeat
    pfam12796
    Location:286 → 353
    Ank_2; Ankyrin repeats (3 copies)
    pfam18716
    Location:539 → 578
    VATC; Vms1-associating treble clef domain
    pfam18826
    Location:1 → 141
    bVLRF1; bacteroidetes VLRF1 release factor

  7. XM_036152348.1 → XP_036008241.1  tRNA endonuclease ANKZF1 isoform X2

    Conserved Domains (6) summary
    PTZ00322
    Location:323 → 395
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:322 → 353
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:323 → 353
    Ank; Ankyrin repeat
    pfam12796
    Location:286 → 353
    Ank_2; Ankyrin repeats (3 copies)
    pfam18716
    Location:539 → 578
    VATC; Vms1-associating treble clef domain
    pfam18826
    Location:1 → 141
    bVLRF1; bacteroidetes VLRF1 release factor

RNA

  1. XR_004933624.1 RNA Sequence

    Related
    ENSMUST00000131788.9

  2. XR_003956227.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UU1.2 GenPept UniProtKB/Swiss-Prot:Q80UU1

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