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PCBP3 poly(rC) binding protein 3 [ Homo sapiens (human) ]

Gene ID: 54039, updated on 3-Nov-2024

Summary

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Official Symbol
PCBP3provided by HGNC
Official Full Name
poly(rC) binding protein 3provided by HGNC
Primary source
HGNC:HGNC:8651
See related
Ensembl:ENSG00000183570 MIM:608502; AllianceGenome:HGNC:8651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCBP3OT; ALPHA-CP3; PCBP3-OT1
Summary
This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Expression
Broad expression in testis (RPKM 8.3), endometrium (RPKM 4.4) and 17 other tissues See more
Orthologs
mouse all
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Genomic context

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See PCBP3 in Genome Data Viewer
Location:
21q22.3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (45643725..45942450)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (44013409..44318564)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (47063639..47362364)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene collagen type XVIII alpha 1 chain Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46934825-46935332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46935840-46936346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18591 Neighboring gene Sharpr-MPRA regulatory region 1559 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:46948644-46948814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46954106-46954980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13403 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46962482-46962994 Neighboring gene solute carrier family 19 member 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:46970045-46970201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46975660-46976554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46980259-46980968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46998853-46999354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47001008-47001944 Neighboring gene uncharacterized LOC107985485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47009554-47010054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47015623-47016124 Neighboring gene Sharpr-MPRA regulatory region 7423 Neighboring gene MPRA-validated peak4424 silencer Neighboring gene MPRA-validated peak4426 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47031725-47032226 Neighboring gene long intergenic non-protein coding RNA 1694 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:47053121-47054320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47057095-47057612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13411 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:47204393-47205264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47236921-47237422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47237423-47237922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47241669-47242354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47244540-47245132 Neighboring gene MPRA-validated peak4427 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47255439-47255946 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47257017-47257560 Neighboring gene PCBP3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47274544-47275220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47275221-47275896 Neighboring gene uncharacterized LOC124905044 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:47278335-47279534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47300489-47301293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47308837-47309710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47309711-47310583 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47312061-47312782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47317748-47318248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47318249-47318749 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:47336390-47336616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47339089-47339588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47371642-47372327 Neighboring gene Sharpr-MPRA regulatory region 9072 Neighboring gene uncharacterized LOC101928796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47393951-47394751 Neighboring gene uncharacterized LOC105372841 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:47401442-47402304

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Targeting a KH-domain protein with RNA decoys. Makeyev AV, et al. RNA, 2002 Sep. PMID 12358435, Free PMC Article
  2. Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations. Wang Y, et al. Gene, 2010 Feb 1. PMID 19914360, Free PMC Article
  3. Proteomic Identification of FLT3 and PCBP3 as Potential Prognostic Biomarkers for Pancreatic Cancer. Ger M, et al. Anticancer Res, 2018 Oct. PMID 30275197
  4. LncRNA A2M-AS1 Promotes Ferroptosis in Pancreatic Cancer via Interacting With PCBP3. Qiu X, et al. Mol Cancer Res, 2022 Nov 3. PMID 35920801
  5. The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. Makeyev AV, et al. RNA, 2002 Mar. PMID 12003487, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA A2M-AS1 Promotes Ferroptosis in Pancreatic Cancer via Interacting With PCBP3.
    Title: LncRNA A2M-AS1 Promotes Ferroptosis in Pancreatic Cancer via Interacting With PCBP3.
  2. Low PCBP3 expression is associated with Pancreatic ductal adenocarcinoma.
    Title: Proteomic Identification of FLT3 and PCBP3 as Potential Prognostic Biomarkers for Pancreatic Cancer.
  3. Study examined splicing factors located on chromosome 21 for their effect on tau exon 10 and discovered that one of them, hnRNPE3 (PCBP3), modestly activates splicing of exon 10 by interacting with its proximal downstream intron around position +19.
    Title: Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of poly(rC) binding protein 3 (PCBP3) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44028

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C-rich single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA metabolic process NAS
Non-traceable Author Statement
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
located_in extracellular exosome HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
poly(rC)-binding protein 3
Names
PCBP3 overlapping transcript 1
PCBP3-overlapping transcript
poly(rC) binding protein 3 overlapping transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130141.2 → NP_001123613.1  poly(rC)-binding protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001123613.1

    Status: REVIEWED

    Source sequence(s)
    AJ011931, AJ239328, AL592528
    Consensus CDS
    CCDS46652.1
    UniProtKB/TrEMBL
    J3QT27
    Related
    ENSP00000383163.1, ENST00000400308.5
    Conserved Domains (2) summary
    cd00105
    Location:269 → 331
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:131 → 195
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

  2. NM_001348238.2 → NP_001335167.1  poly(rC)-binding protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 15, encodes isoform 3.
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    Consensus CDS
    CCDS86994.1
    UniProtKB/TrEMBL
    J3QT27
    Conserved Domains (1) summary
    cl00098
    Location:285 → 359
    KH-I; K homology (KH) RNA-binding domain, type I

  3. NM_001348239.2 → NP_001335168.1  poly(rC)-binding protein 3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    UniProtKB/TrEMBL
    Q5MJP6
    Conserved Domains (2) summary
    cd02396
    Location:131 → 195
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:317 → 381
    KH_1; KH domain

  4. NM_001348240.2 → NP_001335169.1  poly(rC)-binding protein 3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 16, encodes the longest isoform (5).
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    UniProtKB/TrEMBL
    Q5MJP6
    Conserved Domains (1) summary
    cl00098
    Location:309 → 383
    KH-I; K homology (KH) RNA-binding domain, type I

  5. NM_001348241.2 → NP_001335170.1  poly(rC)-binding protein 3 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    UniProtKB/TrEMBL
    J3QT27
    Conserved Domains (2) summary
    cd02396
    Location:131 → 195
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:306 → 370
    KH_1; KH domain

  6. NM_001348242.2 → NP_001335171.1  poly(rC)-binding protein 3 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 13, encodes isoform 7.
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    UniProtKB/TrEMBL
    Q5MJP6
    Conserved Domains (3) summary
    cd22519
    Location:93 → 171
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:254 → 328
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cl00098
    Location:6 → 82
    KH-I; K homology (KH) RNA-binding domain, type I

  7. NM_001348243.2 → NP_001335172.1  poly(rC)-binding protein 3 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL592528
    UniProtKB/TrEMBL
    J3QT27
    Conserved Domains (2) summary
    cd02396
    Location:131 → 195
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:274 → 338
    KH_1; KH domain

  8. NM_001348244.2 → NP_001335173.1  poly(rC)-binding protein 3 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AJ011931, AK094301, AL592528
    Consensus CDS
    CCDS86993.1
    UniProtKB/TrEMBL
    J3QT27
    Related
    ENSP00000383165.1, ENST00000400310.5
    Conserved Domains (2) summary
    cd02396
    Location:131 → 195
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:275 → 339
    KH_1; KH domain

  9. NM_001348245.2 → NP_001335174.1  poly(rC)-binding protein 3 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AJ011931, AJ239328, AL592528
    UniProtKB/TrEMBL
    Q5MJP6
    Conserved Domains (2) summary
    cd02396
    Location:131 → 195
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:297 → 361
    KH_1; KH domain

  10. NM_001382276.1 → NP_001369205.1  poly(rC)-binding protein 3 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 7, encodes isoform 7.
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    UniProtKB/TrEMBL
    Q5MJP6
    Conserved Domains (3) summary
    cd22519
    Location:93 → 171
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:254 → 328
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cl00098
    Location:6 → 82
    KH-I; K homology (KH) RNA-binding domain, type I

  11. NM_001382277.1 → NP_001369206.1  poly(rC)-binding protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL592528
    Consensus CDS
    CCDS42974.2
    UniProtKB/Swiss-Prot
    A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
    UniProtKB/TrEMBL
    J3QT27
    Conserved Domains (3) summary
    cd22516
    Location:38 → 114
    KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22519
    Location:125 → 203
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:286 → 360
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

  12. NM_001382278.1 → NP_001369207.1  poly(rC)-binding protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AJ011931, AJ239328, AL592528
    Consensus CDS
    CCDS86994.1
    UniProtKB/TrEMBL
    J3QT27
    Related
    ENSP00000383164.1, ENST00000400309.5
    Conserved Domains (1) summary
    cl00098
    Location:285 → 359
    KH-I; K homology (KH) RNA-binding domain, type I

  13. NM_001382279.1 → NP_001369208.1  poly(rC)-binding protein 3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 5, encodes the longest isoform (5).
    Source sequence(s)
    AJ011931, AJ239328, AL592528
    UniProtKB/TrEMBL
    Q5MJP6
    Related
    ENSP00000401198.2, ENST00000449640.5
    Conserved Domains (1) summary
    cl00098
    Location:309 → 383
    KH-I; K homology (KH) RNA-binding domain, type I

  14. NM_001382281.1 → NP_001369210.1  poly(rC)-binding protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
    Source sequence(s)
    AJ011931, AJ239328, AL133493, AL592528
    Consensus CDS
    CCDS42974.2
    UniProtKB/Swiss-Prot
    A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
    UniProtKB/TrEMBL
    J3QT27
    Conserved Domains (3) summary
    cd22516
    Location:38 → 114
    KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22519
    Location:125 → 203
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:286 → 360
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

  15. NM_001382282.1 → NP_001369211.1  poly(rC)-binding protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    Consensus CDS
    CCDS42974.2
    UniProtKB/Swiss-Prot
    A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
    UniProtKB/TrEMBL
    J3QT27
    Conserved Domains (3) summary
    cd22516
    Location:38 → 114
    KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22519
    Location:125 → 203
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:286 → 360
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

  16. NM_001382283.1 → NP_001369212.1  poly(rC)-binding protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    Consensus CDS
    CCDS42974.2
    UniProtKB/Swiss-Prot
    A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
    UniProtKB/TrEMBL
    J3QT27
    Conserved Domains (3) summary
    cd22516
    Location:38 → 114
    KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22519
    Location:125 → 203
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:286 → 360
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

  17. NM_001382284.1 → NP_001369213.1  poly(rC)-binding protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    Consensus CDS
    CCDS42974.2
    UniProtKB/Swiss-Prot
    A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
    UniProtKB/TrEMBL
    J3QT27
    Conserved Domains (3) summary
    cd22516
    Location:38 → 114
    KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22519
    Location:125 → 203
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:286 → 360
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

  18. NM_001382285.1 → NP_001369214.1  poly(rC)-binding protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    Consensus CDS
    CCDS42974.2
    UniProtKB/Swiss-Prot
    A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
    UniProtKB/TrEMBL
    J3QT27
    Conserved Domains (3) summary
    cd22516
    Location:38 → 114
    KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22519
    Location:125 → 203
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:286 → 360
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

  19. NM_001382286.1 → NP_001369215.1  poly(rC)-binding protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    Consensus CDS
    CCDS42974.2
    UniProtKB/Swiss-Prot
    A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
    UniProtKB/TrEMBL
    J3QT27
    Conserved Domains (3) summary
    cd22516
    Location:38 → 114
    KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22519
    Location:125 → 203
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:286 → 360
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

  20. NM_001382287.1 → NP_001369216.1  poly(rC)-binding protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    Consensus CDS
    CCDS42974.2
    UniProtKB/Swiss-Prot
    A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
    UniProtKB/TrEMBL
    J3QT27
    Related
    ENSP00000383168.1, ENST00000400314.5
    Conserved Domains (3) summary
    cd22516
    Location:38 → 114
    KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22519
    Location:125 → 203
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:286 → 360
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

  21. NM_001382288.1 → NP_001369217.1  poly(rC)-binding protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    Consensus CDS
    CCDS42974.2
    UniProtKB/Swiss-Prot
    A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
    UniProtKB/TrEMBL
    J3QT27
    Conserved Domains (3) summary
    cd22516
    Location:38 → 114
    KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22519
    Location:125 → 203
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:286 → 360
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

  22. NM_001384156.1 → NP_001371085.1  poly(rC)-binding protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528
    Consensus CDS
    CCDS42974.2
    UniProtKB/Swiss-Prot
    A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
    UniProtKB/TrEMBL
    J3QT27
    Related
    ENSP00000505796.1, ENST00000681687.1
    Conserved Domains (3) summary
    cd22516
    Location:38 → 114
    KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22519
    Location:125 → 203
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:286 → 360
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

  23. NM_020528.3 → NP_065389.2  poly(rC)-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_065389.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 14 and 17-25, encodes isoform 1.
    Source sequence(s)
    AJ011931, AJ239328, AL592528
    Consensus CDS
    CCDS42974.2
    UniProtKB/Swiss-Prot
    A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
    UniProtKB/TrEMBL
    J3QT27
    Conserved Domains (3) summary
    cd22516
    Location:38 → 114
    KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22519
    Location:125 → 203
    KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    cd22522
    Location:286 → 360
    KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

RNA

  1. NR_145492.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AJ011931, AJ239328, AL133492, AL133493, AL592528

  2. NR_145493.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AJ011931, AJ239328, AL592528

  3. NR_189734.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    CP068257

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    45643725..45942450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    44013409..44318564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57721.2 GenPept UniProtKB/Swiss-Prot:P57721

Gene LinkOut

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