islr2 immunoglobulin superfamily containing leucine-rich repeat 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: islr2provided by ZNC
Official Full Name: immunoglobulin superfamily containing leucine-rich repeat 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050320-95
See related: Ensembl:ENSDARG00000051875 AllianceGenome:ZFIN:ZDB-GENE-050320-95
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101901
Summary: Acts upstream of or within retinal ganglion cell axon guidance. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in nervous system. Orthologous to human ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (22635166..22639133, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (22537618..22541631, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we identify a novel role for the LRR receptor Islr2 in ensuring proper axon navigation at the optic chiasm of both zebrafish and mouse.
Title: The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: immunoglobulin superfamily containing leucine-rich repeat protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013523.1 → NP_001013541.1 immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor

See identical proteins and their annotated locations for NP_001013541.1

Status: PROVISIONAL

Source sequence(s)

BC090831

Related

ENSDARP00000068073.4, ENSDART00000073583.5

Conserved Domains (6) summary

smart00082
Location:183 → 221

LRRCT; Leucine rich repeat C-terminal domain

smart00410
Location:252 → 345

IG_like; Immunoglobulin like

cd00116
Location:47 → 184

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:35 → 53

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:102 → 161

LRR_8; Leucine rich repeat

cl11960
Location:256 → 345

Ig; Immunoglobulin domain