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Spag5 sperm associated antigen 5 [ Mus musculus (house mouse) ]

Gene ID: 54141, updated on 28-Oct-2024

Summary

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Official Symbol
Spag5provided by MGI
Official Full Name
sperm associated antigen 5provided by MGI
Primary source
MGI:MGI:1927470
See related
Ensembl:ENSMUSG00000002055 AllianceGenome:MGI:1927470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S17; MAP126; Deepest; Mastrin; D11Bhm180e
Summary
Predicted to enable microtubule binding activity. Acts upstream of or within establishment of spindle orientation. Located in ciliary basal body; ciliary rootlet; and mitotic spindle. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SPAG5 (sperm associated antigen 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in CNS E11.5 (RPKM 16.1), testis adult (RPKM 15.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Spag5 in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78192412..78213283)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78301470..78322457)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene bridge-like lipid transfer protein family member 2 Neighboring gene predicted gene 3948 Neighboring gene ribosomal protein S6 kinase related Neighboring gene STARR-positive B cell enhancer ABC_E9832 Neighboring gene STARR-positive B cell enhancer ABC_E906 Neighboring gene aldolase C, fructose-bisphosphate Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class S

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted disruption of the testicular SPAG5/deepest protein does not affect spermatogenesis or fertility. Xue J, et al. Mol Cell Biol, 2002 Apr. PMID 11884588, Free PMC Article
  2. Astrin regulates meiotic spindle organization, spindle pole tethering and cell cycle progression in mouse oocytes. Yuan J, et al. Cell Cycle, 2009 Oct 15. PMID 19806032
  3. SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE(-/-) mice. Guo L, et al. BMC Cardiovasc Disord, 2024 May 28. PMID 38807081, Free PMC Article
  4. Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein. Mack GJ, et al. Proc Natl Acad Sci U S A, 2001 Dec 4. PMID 11724960, Free PMC Article
  5. Expression and promoter analysis of mouse mastrin gene. Chang MS, et al. Biochem Biophys Res Commun, 2003 Aug 1. PMID 12893248

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE[-/-] mice.
    Title: SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE(-/-) mice.
  2. Loss-of-function of Astrin by RNAi and overexpression of the coiled-coil domain results in spindle disorganization, chromosome misalignment and meiosis progression arrest.
    Title: Astrin regulates meiotic spindle organization, spindle pole tethering and cell cycle progression in mouse oocytes.
  3. cloning and genomic structure of mastrin; mastrin protein was demonstrated to localize to mitotic spindles during mitosis[masatrin]
    Title: Expression and promoter analysis of mouse mastrin gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within establishment of spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of intracellular transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to centrosome IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of attachment of spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of metaphase plate congression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of metaphase plate congression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spindle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary rootlet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule plus-end ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
sperm-associated antigen 5
Names
astrin
microtubule-associated protein
mitotic spindle-associated protein p126

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017407.3 → NP_059103.1  sperm-associated antigen 5

    See identical proteins and their annotated locations for NP_059103.1

    Status: VALIDATED

    Source sequence(s)
    AL591070
    Consensus CDS
    CCDS25098.1
    UniProtKB/Swiss-Prot
    B1AQC8, Q7TME2, Q8CH61
    Related
    ENSMUSP00000045286.4, ENSMUST00000045026.4
    Conserved Domains (1) summary
    COG1196
    Location:524 → 1144
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. NR_156178.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591070

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78192412..78213283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156853.1 → XP_036012746.1  sperm-associated antigen 5 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:1 → 568
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:58 → 313
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_001780027.2 RNA Sequence

  2. XR_001780026.2 RNA Sequence

  3. XR_004936991.1 RNA Sequence

  4. XR_004936992.1 RNA Sequence

  5. XR_003949480.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TME2.1 GenPept UniProtKB/Swiss-Prot:Q7TME2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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