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smyd2a SET and MYND domain containing 2a [ Danio rerio (zebrafish) ]

Gene ID: 541423, updated on 2-Nov-2024

Summary

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Official Symbol
smyd2aprovided by ZNC
Official Full Name
SET and MYND domain containing 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050320-126
See related
Ensembl:ENSDARG00000055151 AllianceGenome:ZFIN:ZDB-GENE-050320-126
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
smyd2; im:7146196; wu:fc02f02; zgc:110553
Summary
Predicted to enable RNA polymerase II complex binding activity and histone H3K36 methyltransferase activity. Acts upstream of or within several processes, including caudal fin development; heart contraction; and regulation of sarcomere organization. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in heart primordium; muscle cell; and somite. Orthologous to human SMYD2 (SET and MYND domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See smyd2a in Genome Data Viewer
Location:
chromosome: 17
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (32745763..32779439, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (32793252..32826928, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene potassium channel, subfamily K, member 2a Neighboring gene uncharacterized LOC101884596 Neighboring gene centromere protein F Neighboring gene prospero homeobox 1a Neighboring gene uncharacterized LOC137488119 Neighboring gene uncharacterized LOC103909051 Neighboring gene sorting nexin 9a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization. Donlin LT, et al. Genes Dev, 2012 Jan 15. PMID 22241783, Free PMC Article
  2. Proper Activity of Histone H3 Lysine 4 (H3K4) Methyltransferase Is Required for Morphogenesis during Zebrafish Cardiogenesis. Kim JD, et al. Mol Cells, 2015 Jun. PMID 25997738, Free PMC Article
  3. Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function. Voelkel T, et al. Biochim Biophys Acta, 2013 Apr. PMID 23047121
  4. SMYD2 is induced during cell differentiation and participates in early development. Sesé B, et al. Int J Dev Biol, 2013. PMID 23873367
  5. The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase. She P, et al. Development, 2020 Sep 28. PMID 32988975, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA polymerase II complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3K36 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3K4 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within caudal fin development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heart contraction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-lysine dimethylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-lysine monomethylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA damage response, signal transduction by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
N-lysine methyltransferase SMYD2-A
Names
SET and MYND domain containing 2
SET and MYND domain-containing protein 2A
histone methyltransferase SMYD2-A
NP_001013568.1
XP_068070504.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013550.1 → NP_001013568.1  N-lysine methyltransferase SMYD2-A

    See identical proteins and their annotated locations for NP_001013568.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091465
    UniProtKB/Swiss-Prot
    Q5BJI7
    Related
    ENSDARP00000071926.5, ENSDART00000077459.6
    Conserved Domains (3) summary
    pfam00856
    Location:204 → 240
    SET; SET domain
    pfam01753
    Location:52 → 90
    zf-MYND; MYND finger
    pfam13424
    Location:339 → 412
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    32745763..32779439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214403.1 → XP_068070504.1  N-lysine methyltransferase SMYD2-A isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BJI7.1 GenPept UniProtKB/Swiss-Prot:Q5BJI7

Gene LinkOut

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