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Sprn shadow of prion protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 541462, updated on 2-Nov-2024

Summary

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Official Symbol
Sprnprovided by RGD
Official Full Name
shadow of prion proteinprovided by RGD
Primary source
RGD:1561845
See related
EnsemblRapid:ENSRNOG00000067971 AllianceGenome:RGD:1561845
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in several cellular components, including cytosol; nucleolus; and vesicle. Predicted to be active in nucleus. Orthologous to human SPRN (shadow of prion protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 307.1), Brain (RPKM 215.0) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sprn in Genome Data Viewer
Location:
1q41
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (204373936..204378074, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194944602..194948448, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (212619817..212623686, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene polyamine oxidase Neighboring gene mitochondrial ribosome-associated GTPase 1 Neighboring gene olfactory receptor family 6 subfamily A member E1 Neighboring gene olfactory receptor family 6 subfamily F member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The highly conserved, N-terminal (RXXX)8 motif of mouse Shadoo mediates nuclear accumulation. Tóth E, et al. Biochim Biophys Acta, 2013 May. PMID 23360978
  2. Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency. Daude N, et al. Proc Natl Acad Sci U S A, 2012 Jun 5. PMID 22619325, Free PMC Article
  3. Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein. Premzl M, et al. Gene, 2003 Sep 18. PMID 14527721
  4. Evolution of vertebrate genes related to prion and Shadoo proteins--clues from comparative genomic analysis. Premzl M, et al. Mol Biol Evol, 2004 Dec. PMID 15342797
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nucleic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
shadow of prion protein
Names
Shadoo
protein shadoo
shadow of prion protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031845.1 → NP_001027015.1  shadow of prion protein precursor

    See identical proteins and their annotated locations for NP_001027015.1

    Status: PROVISIONAL

    Source sequence(s)
    BN000520
    UniProtKB/Swiss-Prot
    Q5BIV7
    UniProtKB/TrEMBL
    A6HXH7
    Conserved Domains (1) summary
    pfam14999
    Location:38 → 147
    Shadoo; Shadow of prion protein, neuroprotective

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    204373936..204378074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271934.1 → XP_063128004.1  shadow of prion protein isoform X1

    UniProtKB/TrEMBL
    A6HXH6

  2. XM_006230573.5 → XP_006230635.1  shadow of prion protein isoform X2

    See identical proteins and their annotated locations for XP_006230635.1

    UniProtKB/Swiss-Prot
    Q5BIV7
    UniProtKB/TrEMBL
    A6HXH7
    Related
    ENSRNOP00000101270.1, ENSRNOT00000132904.1
    Conserved Domains (1) summary
    pfam14999
    Location:38 → 147
    Shadoo; Shadow of prion protein, neuroprotective
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BIV7.1 GenPept UniProtKB/Swiss-Prot:Q5BIV7

Gene LinkOut

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