lifra LIF receptor subunit alpha a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lifraprovided by ZNC
Official Full Name: LIF receptor subunit alpha aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050327-16
See related: Ensembl:ENSDARG00000098857 AllianceGenome:ZFIN:ZDB-GENE-050327-16
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lifr.a; zgc:112989
Summary: Predicted to enable cytokine binding activity and cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and positive regulation of cell population proliferation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in osteochondrodysplasia and primary localized cutaneous amyloidosis 1. Orthologous to several human genes including LIFR (LIF receptor subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (8417184..8483537, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (7912546..7978899, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: LIF receptor subunit alpha a

Names: leukemia inhibitory factor receptor alpha a; leukemia inhibitory factor receptor.a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014306.2 → NP_001014328.2 LIF receptor subunit alpha a precursor

Status: VALIDATED

Source sequence(s)

CR318610

UniProtKB/TrEMBL

A0A0R4IC29, A0A0R4IE17, A0A8M1N4U6

Related

ENSDARP00000131197.2, ENSDART00000157423.2

Conserved Domains (3) summary

smart00060
Location:601 → 672

FN3; Fibronectin type 3 domain

cd00063
Location:506 → 577

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:133 → 190

Lep_receptor_Ig; Ig-like C2-type domain