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Iqgap2 IQ motif containing GTPase activating protein 2 [ Mus musculus (house mouse) ]

Gene ID: 544963, updated on 2-Nov-2024

Summary

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Official Symbol
Iqgap2provided by MGI
Official Full Name
IQ motif containing GTPase activating protein 2provided by MGI
Primary source
MGI:MGI:2449975
See related
Ensembl:ENSMUSG00000021676 AllianceGenome:MGI:2449975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A630053O10; 4933417J23Rik
Summary
Predicted to enable several functions, including Arp2/3 complex binding activity; GTPase activator activity; and calmodulin binding activity. Predicted to be involved in actin filament organization; regulation of actin cytoskeleton organization; and thrombin-activated receptor signaling pathway. Located in microvillus. Is expressed in several structures, including alimentary system; axial skeleton; central nervous system; genitourinary system; and liver. Used to study hepatocellular carcinoma. Orthologous to human IQGAP2 (IQ motif containing GTPase activating protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in placenta adult (RPKM 18.9), liver E18 (RPKM 15.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Iqgap2 in Genome Data Viewer
Location:
13 D1; 13 50.26 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95763685..96028788, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95627177..95892280, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32640 Neighboring gene STARR-seq mESC enhancer starr_35328 Neighboring gene coagulation factor II thrombin receptor Neighboring gene predicted gene, 33074 Neighboring gene predicted gene, 48745 Neighboring gene predicted gene, 52062 Neighboring gene STARR-seq mESC enhancer starr_35329 Neighboring gene coagulation factor II thrombin receptor like 2 Neighboring gene predicted gene, 32702 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:96662105-96662214 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:96662521-96662711 Neighboring gene predicted gene, 24032 Neighboring gene STARR-positive B cell enhancer mm9_chr13:96730579-96730880 Neighboring gene synaptic vesicle glycoprotein 2c Neighboring gene predicted gene, 57605

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling. Sen A, et al. J Biol Chem, 2023 Nov. PMID 37805137, Free PMC Article
  2. Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake. Chiariello CS, et al. Regul Pept, 2012 Jan 10. PMID 21968151, Free PMC Article
  3. Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma. Gnatenko DV, et al. PLoS One, 2013. PMID 23951254, Free PMC Article
  4. Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent. Schmidt VA, et al. Mol Cell Biol, 2008 Mar. PMID 18180285, Free PMC Article
  5. Dnmt3a restrains mast cell inflammatory responses. Leoni C, et al. Proc Natl Acad Sci U S A, 2017 Feb 21. PMID 28167789, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling.
    Title: Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling.
  2. The exacerbated mast cell responses observed in the absence of Dnmt3a were recapitulated or enhanced by treatment with the demethylating agent 5-aza-2'-deoxycytidine as well as by down-modulation of Dnmt1 expression. These effects were in part mediated by the dysregulated expression of the scaffold protein IQGAP2.
    Title: Dnmt3a restrains mast cell inflammatory responses.
  3. found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2
    Title: Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci.
  4. Data show that complete loss of IQ motif-containing GTPase-activating protein 2 (IQGAP2) gene leads to protection from dextran sulfate sodium (DSS)-induced colitis.
    Title: IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.
  5. Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma.
    Title: Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma.
  6. Phosphoinositide module is defined by a C-terminal 105-107 amino acid region of which IQGAP1 and -2, but not IQGAP3, binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)).
    Title: IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.
  7. murine IQGAP2 selectively regulates the facilitated phase of hepatic fatty acid uptake both in vitro and in vivo
    Title: Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake.
  8. Development of hepatocellular carcinoma in Iqgap2-deficient mice is Iqgap1 dependent.
    Title: Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding IEA
Inferred from Electronic Annotation
more info
  
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in thrombin-activated receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in thrombin-activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ras GTPase-activating-like protein IQGAP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027711.1 → NP_081987.1  ras GTPase-activating-like protein IQGAP2

    See identical proteins and their annotated locations for NP_081987.1

    Status: VALIDATED

    Source sequence(s)
    AK142813, AK147360, CJ201339
    Consensus CDS
    CCDS36753.1
    UniProtKB/Swiss-Prot
    Q3UQ44
    UniProtKB/TrEMBL
    B9EKK3
    Related
    ENSMUSP00000067685.7, ENSMUST00000068603.8
    Conserved Domains (5) summary
    smart00015
    Location:689 → 710
    IQ; Calmodulin-binding motif
    cd05131
    Location:916 → 1274
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:905 → 1257
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam03836
    Location:1367 → 1498
    RasGAP_C; RasGAP C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    95763685..96028788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158092.1 → XP_036013985.1  ras GTPase-activating-like protein IQGAP2 isoform X2

    UniProtKB/TrEMBL
    B9EKK3
    Conserved Domains (4) summary
    smart00015
    Location:726 → 747
    IQ; Calmodulin-binding motif
    cd05131
    Location:953 → 1311
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    COG5261
    Location:821 → 1606
    IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
    cl00030
    Location:53 → 203
    CH_SF; calponin homology (CH) domain superfamily

  2. XM_036158091.1 → XP_036013984.1  ras GTPase-activating-like protein IQGAP2 isoform X1

    UniProtKB/TrEMBL
    B9EKK3
    Conserved Domains (4) summary
    smart00015
    Location:726 → 747
    IQ; Calmodulin-binding motif
    cd05131
    Location:953 → 1311
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    COG5261
    Location:821 → 1612
    IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
    cl00030
    Location:53 → 203
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UQ44.2 GenPept UniProtKB/Swiss-Prot:Q3UQ44

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