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pfklb phosphofructokinase, liver b [ Danio rerio (zebrafish) ]

Gene ID: 550259, updated on 18-Sep-2024

Summary

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Official Symbol
pfklbprovided by ZNC
Official Full Name
phosphofructokinase, liver bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-62
See related
Ensembl:ENSDARG00000099755 AllianceGenome:ZFIN:ZDB-GENE-050417-62
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110298
Summary
Predicted to enable several functions, including 6-phosphofructokinase activity; anion binding activity; and identical protein binding activity. Predicted to be involved in canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and fructose 6-phosphate metabolic process. Predicted to act upstream of or within glycolytic process. Predicted to be located in cytoplasm. Predicted to be part of 6-phosphofructokinase complex. Predicted to be active in membrane. Is expressed in liver; male organism; nervous system; somite; and yolk syncytial layer. Orthologous to human PFKL (phosphofructokinase, liver type). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See pfklb in Genome Data Viewer
Location:
chromosome: 11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (44910353..44932103, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (44871989..44895862, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A3 Neighboring gene zgc:171772 Neighboring gene cilia and flagella associated protein 410 Neighboring gene origin recognition complex, subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations. Qi H, et al. Adv Sci (Weinh), 2021 Sep. PMID 34278746, Free PMC Article
  2. Early leucine programming on protein utilization and mTOR signaling by DNA methylation in zebrafish (Danio rerio). Zhu QS, et al. Nutr Metab (Lond), 2020. PMID 32818036, Free PMC Article
  3. Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish. Gong Y, et al. Gen Comp Endocrinol, 2018 Dec 1. PMID 30102881
  4. Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish. Ding Q, et al. Front Nutr, 2022. PMID 35685883, Free PMC Article
  5. Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR. Chen L, et al. Environ Sci Technol, 2017 Jan 3. PMID 28005350

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 6-phosphofructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 6-phosphofructokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables fructose-6-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in canonical glycolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fructose 6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycolytic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 6-phosphofructokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphofructokinase, liver b
NP_001315318.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328389.1 → NP_001315318.1  phosphofructokinase, liver b

    Status: VALIDATED

    Source sequence(s)
    CU861455, LO017733
    UniProtKB/TrEMBL
    A0A0R4ID68, A0A8M1P3T0
    Related
    ENSDARP00000131945.2, ENSDART00000170345.2
    Conserved Domains (2) summary
    cd00764
    Location:12 → 772
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
    TIGR02478
    Location:15 → 753
    6PF1K_euk; 6-phosphofructokinase, eukaryotic type

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    44910353..44932103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017596.1: Suppressed sequence

    Description
    NM_001017596.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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