srd5a2a steroid-5-alpha-reductase, alpha polypeptide 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: srd5a2aprovided by ZNC
Official Full Name: steroid-5-alpha-reductase, alpha polypeptide 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-199
See related: Ensembl:ENSDARG00000043587 AllianceGenome:ZFIN:ZDB-GENE-050417-199
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fk70d02; zgc:109942; zgc:112208; CH73-233A22.6
Summary: Predicted to enable 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Predicted to be involved in steroid biosynthetic process. Predicted to act upstream of or within cell differentiation; sex differentiation; and steroid metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in intestinal bulb and liver. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (51066783..51073109)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (50422984..50429310)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fk98c07.x1 (e-PCR)
- UniSTS:201825

fk70d02.x1 (e-PCR)
- UniSTS:201444

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in androgen biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sex differentiation	IEA Inferred from Electronic Annotation more info
involved_in steroid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 3-oxo-5-alpha-steroid 4-dehydrogenase 2a

NP_001017703.1

EC 1.3.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.